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Molecules 2018, 23(3), 670; https://doi.org/10.3390/molecules23030670

A Reconstruction Method for the Estimation of Temperatures of Multiple Sources Applied for Nanoparticle-Mediated Hyperthermia

1,†
,
2,†
and
2,3,*
1
Multimodality Molecular Imaging Lab (MMIL), Department of Radiology, School of Medicine, Stanford University, Stanford, CA 94305-5427, USA
2
The Laboratory for Optics and Lasers in Medicine , Department of Biomedical Engineering, Tel Aviv University, Tel-Aviv 6997801, Israel
3
Department of Electrical and Computer Engineering, Whiting School of Engineering, Johns Hopkins University, Baltimore, MD 21218-2608, USA
These authors contributed equally to this work.
*
Author to whom correspondence should be addressed.
Received: 21 December 2017 / Revised: 6 February 2018 / Accepted: 13 February 2018 / Published: 16 March 2018
(This article belongs to the Special Issue Applications of Magnetic Nanoparticles in Biomedicine)
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Abstract

Solid malignant tumors are one of the leading causes of death worldwide. Many times complete removal is not possible and alternative methods such as focused hyperthermia are used. Precise control of the hyperthermia process is imperative for the successful application of such treatment. To that end, this research presents a fast method that enables the estimation of deep tissue heat distribution by capturing and processing the transient temperature at the boundary based on a bio-heat transfer model. The theoretical model is rigorously developed and thoroughly validated by a series of experiments. A 10-fold improvement is demonstrated in resolution and visibility on tissue mimicking phantoms. The inverse problem is demonstrated as well with a successful application of the model for imaging deep-tissue embedded heat sources. Thereby, allowing the physician then ability to dynamically evaluate the hyperthermia treatment efficiency in real time. View Full-Text
Keywords: thermal imaging; frequency modulation; reconstruction; nanoparticles thermal imaging; frequency modulation; reconstruction; nanoparticles
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Steinberg, I.; Tamir, G.; Gannot, I. A Reconstruction Method for the Estimation of Temperatures of Multiple Sources Applied for Nanoparticle-Mediated Hyperthermia. Molecules 2018, 23, 670.

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