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Molecules 2018, 23(3), 635; https://doi.org/10.3390/molecules23030635

Development of Dipicolylamine-Modified Cyclodextrins for the Design of Selective Guest-Responsive Receptors for ATP

1
Department of Materials and Life Sciences, Faculty of Science and Technology, Sophia University, 7-1 Kioi-cho, Chiyoda, Tokyo 102-8554, Japan
2
Department of Current Legal Studies, Faculty of Law, Meiji Gakuin University, 1518 Kamikurata-cho, Totsuka-ku, Yokohama, Kanagawa 244-8539, Japan
3
Graduate School of Medicine, The University of Tokyo, 7-3-1 Hongo, Bunkyo, Tokyo 113-0033, Japan
*
Author to whom correspondence should be addressed.
Academic Editor: Bernard Martel
Received: 27 February 2018 / Revised: 9 March 2018 / Accepted: 11 March 2018 / Published: 12 March 2018
(This article belongs to the Special Issue Cyclodextrin Chemistry 2018)
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Abstract

The construction of supramolecular recognition systems based on specific host–guest interactions has been studied in order to design selective chemical sensors. In this study, guest-responsive receptors for ATP have been designed with cyclodextrins (CyDs) as a basic prototype of the turn-on type fluorescent indicator. We synthesized dipicolylamine (DPA)-modified CyD–Cu2+ complexes (Cu·1α, Cu·1β, and Cu·1γ), and evaluated their recognition capabilities toward phosphoric acid derivatives in water. The UV-Vis absorption and fluorescence spectra revealed that Cu·1β selectively recognized ATP over other organic and inorganic phosphates, and that β-CyD had the most suitable cavity size for complexation with ATP. The 1D and 2D NMR analyses suggested that the ATP recognition was based on the host–guest interaction between the adenine moiety of ATP and the CyD cavity, as well as the recognition of phosphoric moieties by the Cu2+–DPA complex site. The specific interactions between the CyD cavity and the nucleobases enabled us to distinguish ATP from other nucleoside triphosphates, such as guanosine triphosphate (GTP), uridine triphosphate (UTP), and cytidine triphosphate (CTP). This study clarified the basic mechanisms of molecular recognition by modified CyDs, and suggested the potential for further application of CyDs in the design of highly selective supramolecular recognition systems for certain molecular targets in water. View Full-Text
Keywords: supramolecular chemistry; cyclodextrin; ATP recognition; host–guest interaction; NMR analyses supramolecular chemistry; cyclodextrin; ATP recognition; host–guest interaction; NMR analyses
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Yamada, T.; Fujiwara, S.; Fujita, K.; Tsuchido, Y.; Hashimoto, T.; Hayashita, T. Development of Dipicolylamine-Modified Cyclodextrins for the Design of Selective Guest-Responsive Receptors for ATP. Molecules 2018, 23, 635.

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