Next Article in Journal
A Tri-O-Bridged Diels-Alder Adduct from Cortex Mori Radicis
Previous Article in Journal
Synthesis of Novel Reactive Disperse Silicon-Containing Dyes and Their Coloring Properties on Silicone Rubbers
Article Menu
Issue 1 (January) cover image

Export Article

Open AccessArticle
Molecules 2018, 23(1), 131; https://doi.org/10.3390/molecules23010131

Prognostic Significance of Activated Leukocyte Cell Adhesion Molecule (ALCAM) in Association with Promoter Methylation of the ALCAM Gene in Breast Cancer

1
Department of Surgery, School of Medicine, Catholic University of Daegu, Daegu 42471, Korea
2
Department of Pathology, School of Medicine, Catholic University of Daegu, Daegu 42471, Korea
*
Author to whom correspondence should be addressed.
Received: 28 November 2017 / Revised: 24 December 2017 / Accepted: 7 January 2018 / Published: 9 January 2018
(This article belongs to the Special Issue Modulators of Histone Methylation: A Medicinal Chemistry Perspective)
View Full-Text   |   Download PDF [1387 KB, uploaded 9 January 2018]   |  

Abstract

Activated leukocyte cell adhesion molecule (ALCAM) has been implicated in tumorigenesis. In this study, we studied DNA methylation status of the ALCAM gene using pyrosequencing in breast cancer tissues. We analyzed the association between the methylation status of the ALCAM gene and its expression. Also, the effects of inflammation on the ALCAM gene methylation and its expression were investigated. The ALCAM gene methylation was associated with the ALCAM transcripts in tumor tissues. The methylation status of the ALCAM gene was not significantly different between tumor and normal tissues. The level of ALCAM transcripts was associated with the expression of TNFα, NF-κB p50, IL-4, and intratumoral inflammation. The IHC expression of ALCAM was associated with histologic grade, HER2 overexpression and molecular subtype. The expression of TNFα, NF-κB p50, and IL-4 showed significant association with the clinicopathologic characteristics. In conclusion, the ALCAM gene methylation was related to the level of ALCAM transcripts. Also, the level of ALCAM transcripts was associated with the inflammatory markers in breast cancer. Our results suggest that the methylation of the ALCAM gene contributes to the decreased expression of ALCAM. Also, ALCAM is linked to the inflammatory response in breast cancer. View Full-Text
Keywords: activated leukocyte cell adhesion molecule; methylation; inflammation; epigenetics; breast cancer activated leukocyte cell adhesion molecule; methylation; inflammation; epigenetics; breast cancer
Figures

Figure 1

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).
SciFeed

Share & Cite This Article

MDPI and ACS Style

Jeong, Y.J.; Oh, H.K.; Park, S.H.; Bong, J.G. Prognostic Significance of Activated Leukocyte Cell Adhesion Molecule (ALCAM) in Association with Promoter Methylation of the ALCAM Gene in Breast Cancer. Molecules 2018, 23, 131.

Show more citation formats Show less citations formats

Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Related Articles

Article Metrics

Article Access Statistics

1

Comments

[Return to top]
Molecules EISSN 1420-3049 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top