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Molecules 2017, 22(9), 1426; doi:10.3390/molecules22091426

NO-Donor Iron Nitrosyl Complex with N-Ethylthiourea Ligand Exhibits Selective Toxicity to Glioma A172 Cells

1
Institute of Problems of Chemical Physics RAS, Chernogolovka 142432, Russia
2
Medicinal Chemistry Research and Education Center, Moscow Region State University, Moscow 105005, Russia
3
Faculty of Fundamental Physical and Chemical Engineering, M.V. Lomonosov Moscow State University, Moscow 119991, Russia
*
Author to whom correspondence should be addressed.
Received: 10 July 2017 / Accepted: 22 August 2017 / Published: 29 August 2017
(This article belongs to the Special Issue Metal Based Drugs: Opportunities and Challenges)
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Abstract

We studied effects of NO-donor iron nitrosyl complex with N-ethylthiourea ligand (ETM) on normal or tumor-derived cell lines. ETM was mildly toxic to most cell lines studied except the human glioma cell line A172 that proved to be highly sensitive to the complex and underwent cell death after ETM exposure. The high susceptibility of A172 cells to ETM was attributed to its NO-donor properties since no toxicity was detected for the N-ethylthiourea ligand. View Full-Text
Keywords: nitric oxide; NO donor; iron nitrosyl complex; N-ethylthiourea; cytotoxicity; glioma nitric oxide; NO donor; iron nitrosyl complex; N-ethylthiourea; cytotoxicity; glioma
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Sanina, N.; Shmatko, N.; Stupina, T.; Balakina, A.; Terent’ev, A. NO-Donor Iron Nitrosyl Complex with N-Ethylthiourea Ligand Exhibits Selective Toxicity to Glioma A172 Cells. Molecules 2017, 22, 1426.

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