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Molecules 2017, 22(9), 1350; doi:10.3390/molecules22091350

Radiolabeled Dendrimers for Nuclear Medicine Applications

1
Department of Nuclear Medicine, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200080, China
2
Basic Medical College, Ningxia Medical University, Yinchuan 750004, Ningxia, China
*
Author to whom correspondence should be addressed.
Received: 13 July 2017 / Revised: 10 August 2017 / Accepted: 10 August 2017 / Published: 25 August 2017
(This article belongs to the Special Issue Dendrimers in Medicine)
View Full-Text   |   Download PDF [7281 KB, uploaded 25 August 2017]   |  

Abstract

Recent advances in nuclear medicine have explored nanoscale carriers for targeted delivery of various radionuclides in specific manners to improve the effect of diagnosis and therapy of diseases. Due to the unique molecular architecture allowing facile attachment of targeting ligands and radionuclides, dendrimers provide versatile platforms in this filed to build abundant multifunctional radiolabeled nanoparticles for nuclear medicine applications. This review gives special focus to recent advances in dendrimer-based nuclear medicine agents for the imaging and treatment of cancer, cardiovascular and other diseases. Radiolabeling strategies for different radionuclides and several challenges involved in clinical translation of radiolabeled dendrimers are extensively discussed. View Full-Text
Keywords: dendrimers; nuclear medicine; PET; SPECT; radionuclide therapy; radiolabeling dendrimers; nuclear medicine; PET; SPECT; radionuclide therapy; radiolabeling
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Zhao, L.; Zhu, M.; Li, Y.; Xing, Y.; Zhao, J. Radiolabeled Dendrimers for Nuclear Medicine Applications. Molecules 2017, 22, 1350.

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