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Molecules 2017, 22(10), 1581; doi:10.3390/molecules22101581

Function Oriented Molecular Design: Dendrimers as Novel Antimicrobials

1
Organic and Inorganic Chemistry Department, Universidad de Alcalá, Campus Universitario, E-28871 Alcalá de Henares, Spain
2
Research Center on Bioengineering, Biomaterials and Nanomedicine (CIBER-BBN), 28029 Madrid, Spain
3
Department of Experimental Medicine, II University of Naples, Via Costantinopoli 16, 80138 Naples, Italy
4
Interuniversity Research Centre on Bioactive Peptides (CiRPEB), University of Naples “Federico II”, Via Mezzocannone 16, 80134 Naples, Italy
5
Department of Pharmacy, University of Naples “Federico II”, Via Mezzocannone 16, 80134 Napoli, Italy
6
John Felice Rome Center, Loyola University Chicago, Via Massimi 114, 00136 Roma, Italy
*
Authors to whom correspondence should be addressed.
Received: 11 August 2017 / Revised: 8 September 2017 / Accepted: 11 September 2017 / Published: 21 September 2017
(This article belongs to the Special Issue Dendrimers in Medicine)
View Full-Text   |   Download PDF [1670 KB, uploaded 25 September 2017]   |  

Abstract

In recent years innovative nanostructures are attracting increasing interest and, among them, dendrimers have shown several fields of application. Dendrimers can be designed and modified in plentiful ways giving rise to hundreds of different molecules with specific characteristics and functionalities. Biomedicine is probably the field where these molecules find extraordinary applicability, and this is probably due to their multi-valency and to the fact that several other chemicals can be coupled to them to obtain desired compounds. In this review we will describe the different production strategies and the tools and technologies for the study of their characteristics. Finally, we provide a panoramic overview of their applications to meet biomedical needs, especially their use as novel antimicrobials. View Full-Text
Keywords: dendrimers; structure; preparation; delivery; antimicrobial; antibacterial; antiviral; antiparasitic dendrimers; structure; preparation; delivery; antimicrobial; antibacterial; antiviral; antiparasitic
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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García-Gallego, S.; Franci, G.; Falanga, A.; Gómez, R.; Folliero, V.; Galdiero, S.; de la Mata, F.J.; Galdiero, M. Function Oriented Molecular Design: Dendrimers as Novel Antimicrobials. Molecules 2017, 22, 1581.

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