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Molecules 2017, 22(7), 942; doi:10.3390/molecules22070942

Chemical Composition, Antibacterial and Antifungal Activities of Crude Dittrichia viscosa (L.) Greuter Leaf Extracts

1
Faculté des Sciences de Bizerte, Université de Carthage, 7021 Zarzouna, Tunisia
2
Laboratory of Biotechnology and Nuclear Technolog, National Centre of Nuclear Science and Technology (CNSTN), Sidi Thabet Technopark, 2020 Ariana, Tunisia
3
Dipartimento di Medicina Veterinaria, Università degli Studi di Bari, 70010 Valenzano, Italy
4
Laboratory of Natural Substances LR10INRAP02, National Institute of Research and Physico-chemical Analyses, Biotechpole of Sidi Thabet, 2020 Ariana, Tunisia
*
Author to whom correspondence should be addressed.
Academic Editors: Hideyuki Ito, Tsutomu Hatano and Takashi Yoshida
Received: 12 May 2017 / Revised: 31 May 2017 / Accepted: 3 June 2017 / Published: 30 June 2017
View Full-Text   |   Download PDF [407 KB, uploaded 30 June 2017]   |  

Abstract

The small amount of data regarding the antifungal activity of Dittrichia viscosa (L.) Greuter against dermatophytes, Malassezia spp. and Aspergillus spp., associated with the few comparative studies on the antimicrobial activity of methanolic, ethanolic, and butanolic extracts underpins the study herein presented. The total condensed tannin (TCT), phenol (TPC), flavonoid (TFC), and caffeoylquinic acid (CQC) content of methanol, butanol, and ethanol (80% and 100%) extracts of D. viscosa were assessed and their bactericidal and fungicidal activities were evaluated. The antibacterial, anti-Candida and anti-Malassezia activities were evaluated by using the disk diffusion method, whereas the anti-Microsporum canis and anti-Aspergillus fumigatus activities were assessed by studying the toxicity effect of the extracts on vegetative growth, sporulation and germination. The methanolic extract contained the highest TPC and CQC content. It contains several phytochemicals mainly caffeoylquinic acid derivatives as determined by liquid chromatography with photodiode array and electrospray ionisation mass spectrometric detection (LC/PDA/ESI-MS) analysis. All extracts showed an excellent inhibitory effect against bacteria and Candida spp., whereas methanolic extract exhibited the highest antifungal activities against Malassezia spp., M. canis and A. fumigatus strains. The results clearly showed that all extracts, in particular the methanolic extract, might be excellent antimicrobial drugs for treating infections that are life threatening (i.e., Malassezia) or infections that require mandatory treatments (i.e., M. canis or A. fumigatus). View Full-Text
Keywords: Dittrichia viscosa; antifungal activities; Candida spp.; Malassezia spp.; Microsporum canis; Aspergillus fumigates Dittrichia viscosa; antifungal activities; Candida spp.; Malassezia spp.; Microsporum canis; Aspergillus fumigates
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

Rhimi, W.; Ben Salem, I.; Immediato, D.; Saidi, M.; Boulila, A.; Cafarchia, C. Chemical Composition, Antibacterial and Antifungal Activities of Crude Dittrichia viscosa (L.) Greuter Leaf Extracts. Molecules 2017, 22, 942.

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