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Molecules 2017, 22(7), 1195; doi:10.3390/molecules22071195

Anti-Inflammatory Effects of Vitisinol A and Four Other Oligostilbenes from Ampelopsis brevipedunculata var. Hancei

1
Department of Biological Science and Technology, National Pingtung University of Science and Technology, Pingtung 900, Taiwan
2
Research Center for Tropic Agriculture, National Pingtung University of Science and Technology, Pingtung 900, Taiwan
3
Research Center for Austronesian Medicine and Agriculture, National Pingtung University of Science and Technology, Pingtung 900, Taiwan
*
Author to whom correspondence should be addressed.
Received: 4 July 2017 / Revised: 14 July 2017 / Accepted: 14 July 2017 / Published: 17 July 2017
(This article belongs to the Section Natural Products)
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Abstract

In this study, the cytotoxicities and anti-inflammatory activities of five resveratrol derivatives—vitisinol A, (+)-ε-viniferin, (+)-vitisin A, (−)-vitisin B, and (+)-hopeaphenol—isolated from Ampelopsis brevipedunculata var. hancei were evaluated by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay and lipopolysaccharide (LPS)-stimulated RAW264.7 cells, respectively. The result from MTT assay analysis indicated that vitisinol A has lower cytotoxicity than the other four well-known oligostilbenes. In the presence of vitisinol A (5 μM), the significant reduction of inflammation product (nitric oxide, NO) in LPS-induced RAW264.7 cells was measured using Griess reaction assay. In addition, the under-expressed inflammation factors cyclooxygenase-2 (COX-2) and inducible nitric oxide synthase (iNOS) in LPS-induced RAW264.7 cells monitored by Western blotting simultaneously suggested that vitisinol A has higher anti-inflammatory effect compared with other resveratrol derivatives. Finally, the anti-inflammatory effect of vitisinol A was further demonstrated on 12-O-tetradecanoylphorbol 13-acetate (TPA)-induced ear edema in mice. As a preliminary functional evaluation of natural product, the anti-inflammatory effect of vitisinol A is the first to be examined and reported by this study. View Full-Text
Keywords: Ampelopsis brevipedunculata var. hancei; anti-inflammatory effect; oligostilbenes; vitisinol A Ampelopsis brevipedunculata var. hancei; anti-inflammatory effect; oligostilbenes; vitisinol A
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

Chang, C.-I.; Chien, W.-C.; Huang, K.-X.; Hsu, J.-L. Anti-Inflammatory Effects of Vitisinol A and Four Other Oligostilbenes from Ampelopsis brevipedunculata var. Hancei. Molecules 2017, 22, 1195.

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