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Molecules 2017, 22(7), 1126; doi:10.3390/molecules22071126

Design, Synthesis and Bioactivities of Novel 1,4-Pentadien-3-one Derivatives Containing a Substituted Pyrazolyl Moiety

1,2,* , 2
College of Chemistry, Chemical Engineering and Materials Science, Soochow University, Suzhou 215123, China
School of Public Health, Nantong University, Nantong 226019, China
College of Chemistry and Chemical Engineering, Nantong University, Nantong 226019, China
Authors to whom correspondence should be addressed.
Received: 26 May 2017 / Revised: 28 June 2017 / Accepted: 5 July 2017 / Published: 6 July 2017
(This article belongs to the Section Organic Synthesis)
View Full-Text   |   Download PDF [895 KB, uploaded 6 July 2017]   |  


In this study, in order to find novel biologically active penta-1,4-dien-3-one derivatives, a series of penta-1,4-dien-3-one compounds containing a substituted pyrazole subunit were designed and synthesized. Their structures were characterized by 1H-NMR, 13C-NMR and elemental analysis. The preliminary bioassays displayed that most of the title compounds showed significant antiproliferative activity against HepG2 cell lines. Especially, compounds 7am, o, r, s, u, w, y and z were active against HepG2 cells with IC50 values of 0.10–5.05 μM, which were superior to that of the contrast sorafenib (IC50 = 16.20 μM). View Full-Text
Keywords: penta-1,4-dien-3-one; pyrazole; synthesis; biological activity penta-1,4-dien-3-one; pyrazole; synthesis; biological activity

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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

Supplementary material

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    Description: 1H NMR and 13C NMR spectra of pyrazole oxime compounds 7a-7z

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Chen, C.; Chen, J.; Gu, H.; Bao, N.; Dai, H. Design, Synthesis and Bioactivities of Novel 1,4-Pentadien-3-one Derivatives Containing a Substituted Pyrazolyl Moiety. Molecules 2017, 22, 1126.

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