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Molecules 2017, 22(7), 1113; doi:10.3390/molecules22071113

Proteomics Analysis Reveals an Important Role for the PPAR Signaling Pathway in DBDCT-Induced Hepatotoxicity Mechanisms

1,2,* , 1
,
1
and
1,2,*
1
School of Pharmaceutical Science, Shanxi Medical University, Taiyuan 030001, China
2
Department of Traditional Chinese Medicine, Shanxi University of Traditional Chinese Medicine, Taiyuan 030001, China
*
Authors to whom correspondence should be addressed.
Received: 21 May 2017 / Accepted: 28 June 2017 / Published: 6 July 2017
(This article belongs to the Section Medicinal Chemistry)
View Full-Text   |   Download PDF [5707 KB, uploaded 7 July 2017]   |  

Abstract

A patented organotin di-n-butyl-di-(4-chlorobenzohydroxamato)tin (DBDCT) with high a antitumor activity was designed, however, its antitumor and toxic mechanisms have not yet been clearly illustrated. Hepatic proteins of DBDCT-treated rats were identified and analyzed using LC–MS/MS with label-free quantitative technology. In total, 149 differentially expressed proteins were successfully identified. Five protein and mRNA expressions were involved in the peroxisome proliferator-activated receptor (PPAR) signaling pathway, including a scavenger receptor (CD36), adipocyte fatty acid binding protein 4 (FABP4), enoyl-CoA hydratase (EHHADH), acetyl-CoA acyltransferase 1 (ACAA1), and phosphoenolpyruvate carboxykinase (PEPCK) in DBDCT-treated Rat Liver (BRL) cells. PPAR-α and PPAR-λ were also significantly decreased at both protein and mRNA levels. Furthermore, compared with the DBDCT treatment group, a special blocking agent of PPAR-λ T0070907 was used to evaluate the relationship between PPAR-λ and its downstream genes. Our studies indicated that DBDCT may serve as a modulator of PPAR-λ, further up-regulating CD36, FABP4 and EHHADH on the PPAR signal pathway. View Full-Text
Keywords: di-n-butyl-di-(4-chlorobenzohydroxamato)tin(IV) (DBDCT); proteomics; PPAR signaling pathway; hepatotoxicity mechanisms di-n-butyl-di-(4-chlorobenzohydroxamato)tin(IV) (DBDCT); proteomics; PPAR signaling pathway; hepatotoxicity mechanisms
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Li, Y.; Liu, X.; Niu, L.; Li, Q. Proteomics Analysis Reveals an Important Role for the PPAR Signaling Pathway in DBDCT-Induced Hepatotoxicity Mechanisms. Molecules 2017, 22, 1113.

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