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Molecules 2017, 22(6), 975; doi:10.3390/molecules22060975

Targeted Magnetic Nanotheranostics of Cancer

1
Krasnoyarsk State Medical University named after prof. V.F. Voino-Yaseneckii, 660022 Krasnoyarsk, Russia
2
Federal Research Center, KSC Siberian Branch of Russian Academy of Science, 660022 Krasnoyarsk, Russia
3
Independent Researcher Vancouver, Vancouver, BC V6K 1C4, Canada
*
Author to whom correspondence should be addressed.
Received: 19 April 2017 / Revised: 2 June 2017 / Accepted: 6 June 2017 / Published: 12 June 2017
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Abstract

Current advances in targeted magnetic nanotheranostics are summarized in this review. Unique structural, optical, electronic and thermal properties of magnetic materials in nanometer scale are attractive in the field of biomedicine. Magnetic nanoparticles functionalized with therapeutic molecules, ligands for targeted delivery, fluorescent and other chemical agents can be used for cancer diagnostic and therapeutic purposes. High selectivity, small size, and low immunogenicity of synthetic nucleic acid aptamers make them attractive delivery agents for therapeutic purposes. Properties, production and functionalization of magnetic nanoparticles and aptamers as ligands for targeted delivery are discussed herein. In recent years, magnetic nanoparticles have been widely used in diagnostic methods, such as scintigraphy, single photon emission computed tomography (SPECT), positron emission tomography (PET), magnetic resonance imaging (MRI), and Raman spectroscopy. Therapeutic purposes of magnetic nanoconstructions are also promising. They are used for effective drug delivery, magnetic mediated hypertermia, and megnetodynamic triggering of apoptosis. Thus, magnetic nanotheranostics opens a new venue for complex differential diagnostics, and therapy of metastatic cancer. View Full-Text
Keywords: magnetic nanoparticles; aptamers; drug delivery; magnetodynamic therapy; magnetic hyperthermia; magnetophoresis magnetic nanoparticles; aptamers; drug delivery; magnetodynamic therapy; magnetic hyperthermia; magnetophoresis
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Belyanina, I.; Kolovskaya, O.; Zamay, S.; Gargaun, A.; Zamay, T.; Kichkailo, A. Targeted Magnetic Nanotheranostics of Cancer. Molecules 2017, 22, 975.

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