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Molecules 2017, 22(6), 946; doi:10.3390/molecules22060946

Origins, Phytochemistry, Pharmacology, Analytical Methods and Safety of Cortex Moutan (Paeonia suffruticosa Andrew): A Systematic Review

1,2,3
,
2,3,* , 2,3
,
1,* and 2,3
1
School of Pharmacy, Anhui Medical University, Hefei 230032, China
2
Institute of Medicinal Plant Development, Chinese Academy of Medical Science, Peking Union Medical College, Beijing 100193, China
3
Key Laboratory of Bioactive Substances and Resources Utilization of Chinese Herbal Medicine, Ministry of Education, Beijing 100193, China
*
Authors to whom correspondence should be addressed.
Academic Editor: Derek J. McPhee
Received: 17 May 2017 / Revised: 2 June 2017 / Accepted: 3 June 2017 / Published: 7 June 2017
View Full-Text   |   Download PDF [2879 KB, uploaded 7 June 2017]   |  

Abstract

Cortex Moutan (CM), a well-known traditional Chinese medicine, is commonly used for treating various diseases in China and other eastern Asian countries. Recorded in Pharmacopeias of several countries, CM is now drawing increasing attention and under extensive studies in various fields. Phytochemical studies indicate that CM contains many valuable secondary metabolites, such as monoterpene glycosides and phenols. Ample evidence from pharmacological researches suggest that CM has a wide spectrum of activities, such as anti-inflammatory, anti-oxidant, anti-tumor, anti-diabetic, cardiovascular protective, neuroprotective, hepatoprotective effects. Moreover, various analytical methods were established for the quality evaluation and safety control of CM. This review synopsizes updated information concerning the origins, phytochemistry, pharmacology, analytical method and safety of CM, aiming to provide favorable references for modern CM research and application. In conclusion, continuing pharmacological investigations concerning CM should be conducted to unravel its pharmacological mechanisms. Further researches are necessary to obtain comprehensive and applicable analytical approach for quality evaluation and establish harmonized criteria of CM. View Full-Text
Keywords: Cortex Moutan; origins; phytochemistry; pharmacology; safety; Traditional Chinese Medicine Cortex Moutan; origins; phytochemistry; pharmacology; safety; Traditional Chinese Medicine
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Wang, Z.; He, C.; Peng, Y.; Chen, F.; Xiao, P. Origins, Phytochemistry, Pharmacology, Analytical Methods and Safety of Cortex Moutan (Paeonia suffruticosa Andrew): A Systematic Review. Molecules 2017, 22, 946.

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