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Molecules 2017, 22(6), 936; doi:10.3390/molecules22060936

New Benzenoid Derivatives and Other Constituents from Lawsonia inermis with Inhibitory Activity against NO Production

1
Department of Chinese Pharmaceutical Sciences and Chinese Medicine Resources, China Medical University, Taichung 404, Taiwan
2
Faculty of Pharmacy, School of Pharmaceutical Sciences, National Yang-Ming University, Taipei 112, Taiwan
3
Department of Medical Research, China Medical University Hospital, China Medical University, Taichung 404, Taiwan
4
Department of Forestry, National Chung-Hsing University, Taichung 402, Taiwan
5
Agricultural Biotechnology Research Center, Academia Sinica, Taipei 115, Taiwan
6
National Museum of Marine Biology and Aquarium, Pingtung 944, Taiwan
7
Food Industry Research and Development Institute, Hsinchu 300, Taiwan
8
Department of Biotechnology, Asia University, Taichung 413, Taiwan
These authors contributed equally to this work.
*
Author to whom correspondence should be addressed.
Academic Editor: Thomas J. Schmidt
Received: 8 May 2017 / Accepted: 1 June 2017 / Published: 5 June 2017
(This article belongs to the Section Natural Products)
View Full-Text   |   Download PDF [1400 KB, uploaded 5 June 2017]   |  

Abstract

Three new benzenoid derivatives, lawsoinermone (1), inermidioic acid (2), and inermic acid (3) have been isolated from the aerial part of Lawsonia inermis, together with 11 known compounds (414). The structures of three new compounds were determined through spectroscopic and MS analyses. Compounds 1, 46, 13 and 14 were evaluated for inhibition of nitric oxide production in LPS-stimulated product of nitrite in RAW 264.7 cells with IC50 values of 6.12, 16.43, 18.98, 9.30, 9.30 and 14.90 μg/mL, respectively. View Full-Text
Keywords: Lawsonia inermis; lawsoinermone; inermidioic acid; inermic acid; inhibitory activities against NO production Lawsonia inermis; lawsoinermone; inermidioic acid; inermic acid; inhibitory activities against NO production
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MDPI and ACS Style

Yang, C.-S.; Chen, J.-J.; Huang, H.-C.; Huang, G.-J.; Wang, S.-Y.; Sung, P.-J.; Cheng, M.-J.; Wu, M.-D.; Kuo, Y.-H. New Benzenoid Derivatives and Other Constituents from Lawsonia inermis with Inhibitory Activity against NO Production. Molecules 2017, 22, 936.

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