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Molecules 2017, 22(6), 929; doi:10.3390/molecules22060929

Curcumin Inhibits LIN-28A through the Activation of miRNA-98 in the Lung Cancer Cell Line A549

1
Department of Intensive Care Medicine, Chi Mei Medical Center, Liouying, Tainan 73657, Taiwan
2
School of Medicine, College of Medicine, Fu Jen Catholic University, New Taipei 24205, Taiwan
3
Graduate Institute of Medical Sciences, College of Health Sciences, Chang Jung Christian University, Tainan 71101, Taiwan
4
Department of pharmacology, Institute for Drug Evaluation Platform, Development Center for Biotechnology, New Taipei 22180, Taiwan
5
Department of Respiratory Therapy, College of Medicine, Kaohsiung Medical University, Kaohsiung 80756, Taiwan
6
Department of Internal Medicine, Kaohsiung Medical University Hospital, Kaohsiung 80756, Taiwan
7
Department of Pediatrics, Cathay General Hospital, Taipei 10630, Taiwan
8
Graduate Institute of Integrated Medicine, College of Chinese Medicine, China Medical University, Taichung 40407, Taiwan
9
Department of Psychology, College of Medical and Health Science, Asia University, Taichung 41354, Taiwan
10
Division of Hemato-oncology, Department of Internal Medicine, Chi Mei Medical Center, Liouying, Tainan 73657, Taiwan
11
Department of Internal Medicine, Kaohsiung Municipal Ta-Tung Hospital, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung 80145, Taiwan
12
Division of Cardiovascular Surgery, Department of Surgery, Kaohsiung Medical University Hospital, Kaohsiung 80756, Taiwan
*
Author to whom correspondence should be addressed.
Academic Editor: D. Hadjipavlou-Litina
Received: 29 March 2017 / Revised: 4 May 2017 / Accepted: 25 May 2017 / Published: 3 June 2017
View Full-Text   |   Download PDF [2378 KB, uploaded 3 June 2017]   |  

Abstract

Metastasis is common in lung cancer and is associated with poor clinical outcomes and increased mortality. Curcumin is a natural anti-cancer agent that inhibits the metastasis of various cancers by modulating the expression of micro (mi) RNAs such as miR-98, which acts as a tumor suppressor. This study investigated the effect of curcumin on miR-98 expression and in vitro cell line growth and invasiveness in lung cancer. Curcumin treatment enhanced the expression of miR-98 and reduced that of the miR-98 target gene LIN28A as well as matrix metalloproteinase (MMP) 2 and MMP9 in vitro and in vivo. MiR-98 overexpression suppressed lung cancer cell migration and invasion by inhibiting LIN28A-induced MMP2 and MMP9 expression. Meanwhile, LIN28A level was downregulated by overexpression of miR-98 mimic. Induction of miR-98 by curcumin treatment suppressed MMP2 and MMP9 by targeting LIN28A. These findings provide insight into the mechanisms by which curcumin suppresses lung cancer cell line growth in vitro and in vivo and invasiveness in vitro. View Full-Text
Keywords: curcumin; LIN28A; metastasis; miR-98; lung cancer; MMP curcumin; LIN28A; metastasis; miR-98; lung cancer; MMP
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MDPI and ACS Style

Liu, W.-L.; Chang, J.-M.; Chong, I.-W.; Hung, Y.-L.; Chen, Y.-H.; Huang, W.-T.; Kuo, H.-F.; Hsieh, C.-C.; Liu, P.-L. Curcumin Inhibits LIN-28A through the Activation of miRNA-98 in the Lung Cancer Cell Line A549. Molecules 2017, 22, 929.

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