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Molecules 2017, 22(4), 633; doi:10.3390/molecules22040633

Synthesis of Curcuminoids and Evaluation of Their Cytotoxic and Antioxidant Properties

1
Departamento de Sistemas Biológicos, División de Ciencias Biológicas y de la Salud, Universidad Autónoma Metropolitana-Xochimilco (UAM-X.), Ciudad de México 04960, Mexico
2
Instituto de Química, Universidad Nacional Autónoma de México (UNAM), Ciudad de México 04510, Mexico
These authors contributed equally to this work.
This paper was written in memory of Dra. María Concepción Lozada-García.
*
Authors to whom correspondence should be addressed.
Academic Editor: D. Hadjipavlou-Litina
Received: 23 February 2017 / Revised: 4 April 2017 / Accepted: 11 April 2017 / Published: 14 April 2017
View Full-Text   |   Download PDF [651 KB, uploaded 14 April 2017]   |  

Abstract

Curcumin (1) and ten derivatives (211) were synthesized and evaluated as cytotoxic and antioxidant agents. The results of primary screening by Sulforhodamine B assay against five human cancer cell lines (U-251 MG, glioblastoma; PC-3, human prostatic; HCT-15, human colorectal; K562, human chronic myelogenous leukemia; and SKLU-1, non-small cell lung cancer) allowed us to calculate the half maximal inhibitory concentration (IC50) values for the more active compounds against HCT-15 and K562 cell lines. Compounds 2 and 10 were the most active against both cell lines and were more active than curcumin itself. Thiobarbituric acid reactive substances (TBARS) assay showed that 7 has potent activity; even stronger than curcumin, α-tocopherol, and quercetin. View Full-Text
Keywords: antioxidant; azoles; cytotoxic; curcumin antioxidant; azoles; cytotoxic; curcumin
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Lozada-García, M.C.; Enríquez, R.G.; Ramírez-Apán, T.O.; Nieto-Camacho, A.; Palacios-Espinosa, J.F.; Custodio-Galván, Z.; Soria-Arteche, O.; Pérez-Villanueva, J. Synthesis of Curcuminoids and Evaluation of Their Cytotoxic and Antioxidant Properties. Molecules 2017, 22, 633.

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