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Molecules 2017, 22(6), 878; doi:10.3390/molecules22060878

Design, Synthesis, and Biological Activities of Novel Pyrazole Oxime Compounds Containing a Substituted Pyridyl Moiety

1,2
,
3
,
1,2,* , 2
and
3,*
1
College of Chemistry, Chemical Engineering and Materials Science, Soochow University, Suzhou 215123, China
2
School of Public Health, Nantong University, Nantong 226019, China
3
College of Chemistry and Chemical Engineering, Nantong University, Nantong 226019, China
*
Authors to whom correspondence should be addressed.
Academic Editor: Jean Jacques Vanden Eynde
Received: 16 April 2017 / Revised: 20 May 2017 / Accepted: 23 May 2017 / Published: 25 May 2017
(This article belongs to the Section Organic Synthesis)
View Full-Text   |   Download PDF [707 KB, uploaded 26 May 2017]   |  

Abstract

In this paper, in order to find novel biologically active pyrazole oximes, a series of pyrazole oxime compounds bearing a substituted pyridyl unit were prepared. Bioassays showed that some target compounds were found to have good acaricidal activity against Tetranychus cinnabarinus at a concentration of 500 μg/mL, compound 9q especially displayed potent acaricidal activity against T. cinnabarinus when the concentration was reduced to 100 μg/mL. Interestingly, most target compounds possessed excellent insecticidal activities against Oriental armyworm at 500 μg/mL. Moreover, some compounds were active against Aphis medicaginis and Nilaparvata lugens at 500 μg/mL. Additionally, compounds 9b, 9g, 9l, 9p, 9q, 9r, 9s, 9t, 9u, and 9v displayed significant antiproliferative activities against HepG2 cells with IC50 values of 1.53–17.27 μM, better than that of the control 5-fluorouracil (IC50 = 35.67 μM). View Full-Text
Keywords: pyrazole oxime; pyridyl; synthesis; biological activity pyrazole oxime; pyridyl; synthesis; biological activity
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    Description: The 1H-NMR and 13C-NMR spectra of the title compounds

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MDPI and ACS Style

Chen, C.; Chen, J.; Gu, H.; Bao, N.; Dai, H. Design, Synthesis, and Biological Activities of Novel Pyrazole Oxime Compounds Containing a Substituted Pyridyl Moiety. Molecules 2017, 22, 878.

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