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Molecules 2017, 22(6), 860; doi:10.3390/molecules22060860

14,15-Secopregnane-Type Glycosides with 5α:9α-Peroxy and Δ6,8(14)-diene Linkages from the Roots of Cynanchum stauntonii

1
State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China
2
Shandong Analysis and Test Center, Shandong Academy of Sciences, Jinan 250014, Shandong, China
*
Author to whom correspondence should be addressed.
Academic Editor: Derek J. McPhee
Received: 21 April 2017 / Revised: 18 May 2017 / Accepted: 19 May 2017 / Published: 23 May 2017
(This article belongs to the Section Natural Products)
View Full-Text   |   Download PDF [716 KB, uploaded 23 May 2017]   |  

Abstract

Three new 14,15-secopregnane-type glycosides, stauntosides UA, UA1, and UA2, were isolated from the roots of Cynanchum stauntonii. The three compounds share the first reported and same basic structural features of 3β-hydroxy-14:16,15:20,18:20-triepoxy-5α:9α-peroxy-14,15-secopregnane-6,8(14)-diene named as stauntogenin G as the aglycones. The structures of the new compounds were characterized on the basis of extensive spectroscopic analyses, mainly 1D and 2D NMR and MS methods and chemical analysis. The isolation and identification of the new compounds graced the structural diversity of pregnane-type steroids from C. stauntonii. View Full-Text
Keywords: Cynanchum stauntonii; Asclepiadaceae; 14,15-secopregnane-type glycoside; stauntogenin G; 5α:9α-peroxy linkage; stauntosides UA, UA1, and UA2; structure elucidation Cynanchum stauntonii; Asclepiadaceae; 14,15-secopregnane-type glycoside; stauntogenin G; 5α:9α-peroxy linkage; stauntosides UA, UA1, and UA2; structure elucidation
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MDPI and ACS Style

Deng, A.-J.; Yu, J.-Q.; Li, Z.-H.; Ma, L.; Zhang, Z.-H.; Qin, H.-L. 14,15-Secopregnane-Type Glycosides with 5α:9α-Peroxy and Δ6,8(14)-diene Linkages from the Roots of Cynanchum stauntonii. Molecules 2017, 22, 860.

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