Phenolic Glycosides from Capsella bursa-pastoris (L.) Medik and Their Anti-Inflammatory Activity
AbstractA new sesquilignan glycoside 1, together with seven known phenolic glycosides 2–8 were isolated from the aerial parts of Capsella bursa-pastoris. The chemical structure of the new compound 1 was elucidated by extensive nuclear magnetic resonance (NMR) data (1H- and 13C-NMR, 1H-1H correlation spectroscopy (1H-1H COSY), heteronuclear single-quantum correlation (HSQC), heteronuclear multiple bond correlation (HMBC), and nuclear overhauser effect spectroscopy (NOESY)) and HR-FABMS analysis. The anti-inflammatory effects of 1–8 were evaluated in lipopolysaccharide (LPS)-stimulated murine microglia BV-2 cells. Compounds 4 and 7 exhibited moderate inhibitory effects on nitric oxide production in LPS-activated BV-2 cells, with IC50 values of 17.80 and 27.91 µM, respectively. View Full-Text
- Supplementary File 1:
Supplementary (PDF, 645 KB)
Externally hosted supplementary file 1
Link: http://supplementary data.docx
Description: Fig. S1 1H NMR spectrum of 1 (700 MHz, CD3OD) Fig. S2 13C NMR spectrum of 1 (175 MHz, CD3OD) Fig. S3 HSQC spectrum of 1 Fig. S4 HMBC spectrum of 1 Fig. S5 1H-1H COSY spectrum of 1 Fig. S6 NOESY spectrum of 1 Fig. S7 HR-FAB-MS spectrum of 1 Fig. S8 CD spectra of compound 1
Share & Cite This Article
Cha, J.M.; Suh, W.S.; Lee, T.H.; Subedi, L.; Kim, S.Y.; Lee, K.R. Phenolic Glycosides from Capsella bursa-pastoris (L.) Medik and Their Anti-Inflammatory Activity. Molecules 2017, 22, 1023.
Cha JM, Suh WS, Lee TH, Subedi L, Kim SY, Lee KR. Phenolic Glycosides from Capsella bursa-pastoris (L.) Medik and Their Anti-Inflammatory Activity. Molecules. 2017; 22(6):1023.Chicago/Turabian Style
Cha, Joon M.; Suh, Won S.; Lee, Tae H.; Subedi, Lalita; Kim, Sun Y.; Lee, Kang R. 2017. "Phenolic Glycosides from Capsella bursa-pastoris (L.) Medik and Their Anti-Inflammatory Activity." Molecules 22, no. 6: 1023.
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.