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Molecules 2017, 22(6), 1023; doi:10.3390/molecules22061023

Phenolic Glycosides from Capsella bursa-pastoris (L.) Medik and Their Anti-Inflammatory Activity

1
Natural Products Laboratory, School of Pharmacy, Sungkyunkwan University, Suwon 16419, Korea
2
Gachon Institute of Pharmaceutical Science, Gachon University, 191 Hambakmoero, Yeonsu-gu, Incheon 21936, Korea
3
College of Pharmacy, Gachon University, 191 Hambakmoero, Yeonsu-gu, Incheon 21936, Korea
*
Author to whom correspondence should be addressed.
Received: 16 May 2017 / Revised: 12 June 2017 / Accepted: 18 June 2017 / Published: 20 June 2017
(This article belongs to the Collection Bioactive Compounds)
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Abstract

A new sesquilignan glycoside 1, together with seven known phenolic glycosides 28 were isolated from the aerial parts of Capsella bursa-pastoris. The chemical structure of the new compound 1 was elucidated by extensive nuclear magnetic resonance (NMR) data (1H- and 13C-NMR, 1H-1H correlation spectroscopy (1H-1H COSY), heteronuclear single-quantum correlation (HSQC), heteronuclear multiple bond correlation (HMBC), and nuclear overhauser effect spectroscopy (NOESY)) and HR-FABMS analysis. The anti-inflammatory effects of 18 were evaluated in lipopolysaccharide (LPS)-stimulated murine microglia BV-2 cells. Compounds 4 and 7 exhibited moderate inhibitory effects on nitric oxide production in LPS-activated BV-2 cells, with IC50 values of 17.80 and 27.91 µM, respectively. View Full-Text
Keywords: Capsella bursa-pastoris; Cruciferae; sesquilignan glycoside; anti-inflammatory Capsella bursa-pastoris; Cruciferae; sesquilignan glycoside; anti-inflammatory
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

Supplementary materials

  • Supplementary File 1:

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    Link: http://supplementary data.docx
    Description: Fig. S1 1H NMR spectrum of 1 (700 MHz, CD3OD) Fig. S2 13C NMR spectrum of 1 (175 MHz, CD3OD) Fig. S3 HSQC spectrum of 1 Fig. S4 HMBC spectrum of 1 Fig. S5 1H-1H COSY spectrum of 1 Fig. S6 NOESY spectrum of 1 Fig. S7 HR-FAB-MS spectrum of 1 Fig. S8 CD spectra of compound 1

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MDPI and ACS Style

Cha, J.M.; Suh, W.S.; Lee, T.H.; Subedi, L.; Kim, S.Y.; Lee, K.R. Phenolic Glycosides from Capsella bursa-pastoris (L.) Medik and Their Anti-Inflammatory Activity. Molecules 2017, 22, 1023.

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