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Molecules 2017, 22(5), 834; doi:10.3390/molecules22050834

Combining Pharmacological Countermeasures to Attenuate the Acute Radiation Syndrome—A Concise Review

Department of Cell Biology and Radiobiology, Institute of Biophysics, v.v.i., Czech Academy of Sciences, Královopolská 135, 61265 Brno, Czech Republic
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Academic Editor: Diego Muñoz-Torrero
Received: 28 March 2017 / Revised: 16 May 2017 / Accepted: 16 May 2017 / Published: 19 May 2017
(This article belongs to the Section Medicinal Chemistry)
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Abstract

The goal of combined pharmacological approaches in the treatment of the acute radiation syndrome (ARS) is to obtain an effective therapy producing a minimum of undesirable side effects. This review summarizes important data from studies evaluating the efficacy of combining radioprotective agents developed for administration prior to irradiation and therapeutic agents administered in a post-irradiation treatment regimen. Many of the evaluated results show additivity, or even synergism, of the combined treatments in comparison with the effects of the individual component administrations. It can be deduced from these findings that the research in which combined treatments with radioprotectors/radiomitigators are explored, tested, and evaluated is well-founded. The requirement for studies highly emphasizing the need to minimize undesirable side effects of the radioprotective/radiomitigating therapies is stressed. View Full-Text
Keywords: acute radiation syndrome; radioprotectors; radiomitigators; combined treatment; cytokines acute radiation syndrome; radioprotectors; radiomitigators; combined treatment; cytokines
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Hofer, M.; Hoferová, Z.; Depeš, D.; Falk, M. Combining Pharmacological Countermeasures to Attenuate the Acute Radiation Syndrome—A Concise Review. Molecules 2017, 22, 834.

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