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Molecules 2017, 22(5), 801; doi:10.3390/molecules22050801

Alcohols as Substrates and Solvents for the Construction of 3-Alkoxylated-2-Oxindoles by Direct Alkoxylation of 3-Halooxindoles

1
Guizhou Medicine Edicine Edible Plant Resources Research and Development Center, College of Pharmacy, Guizhou University, Guiyang 550025, China
2
Key Laboratory for Asymmetric Synthesis & Chirotechnology of Sichuan Province, Chengdu Institute of Organic Chemistry, Chinese Academy of Sciences, Chengdu 610041, China
These two authors contributed equally to this work.
*
Authors to whom correspondence should be addressed.
Academic Editor: Derek J. McPhee
Received: 20 April 2017 / Revised: 11 May 2017 / Accepted: 12 May 2017 / Published: 13 May 2017
(This article belongs to the Section Organic Synthesis)
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Abstract

Described herein is an environmentally benign method for the synthesis of multisubstituted 3-alkoxylated-2-oxindoles 3 via direct alkoxylation of 3-halooxindoles 1. A wide variety of such multisubstituted 3-alkoxylated-2-oxindole scaffolds were smoothly obtained in good yields (up to 94%) by heating in an oil bath at 35 °C for 24 h. A particularly valuable feature of this method was the development of environment-friendly chemistry using alcohols 2 as both the substrates and solvents in the presence of a catalytic amount of base. View Full-Text
Keywords: 3-alkoxylated-2-oxindoles; 3-halooxindoles; alcohols; alkoxylation; environment-friendly chemistry 3-alkoxylated-2-oxindoles; 3-halooxindoles; alcohols; alkoxylation; environment-friendly chemistry
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

Lin, B.; Chen, Z.-Y.; Liu, H.-H.; Wei, Q.-D.; Feng, T.-T.; Zhou, Y.; Wang, C.; Liu, X.-L.; Yuan, W.-C. Alcohols as Substrates and Solvents for the Construction of 3-Alkoxylated-2-Oxindoles by Direct Alkoxylation of 3-Halooxindoles. Molecules 2017, 22, 801.

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