Antigiardial Activity of Podophyllotoxin-Type Lignans from Bursera fagaroides var. fagaroides
AbstractGiardiasis, a diarrheal disease, is highly prevalent in developing countries. Several drugs are available for the treatment of this parasitosis; unfortunately, all of them have variable efficacies and adverse effects. Bursera fagaroides has been known for its anti-inflammatory and antidiarrheal properties in Mexican traditional medicine. We investigated the in vitro anti-giardial activities of four podophyllotoxin-type lignans from Bursera fagaroides var. fagaroides, namely, 5′-desmethoxy-β-peltatin-A-methylether (5-DES), acetylpodophyllotoxin (APOD), burseranin (BUR), and podophyllotoxin (POD). All lignans affected the Giardia adhesion and electron microscopy images revealed morphological alterations in the caudal region, ventral disk, membrane, and flagella, to different extents. Only 5-DES, APOD, and POD caused growth inhibition. Using the Caco-2 human cell line as a model of the intestinal epithelium, we demonstrated that APOD displayed direct antigiardial killing activity and low toxicity on Caco-2 cells. This finding makes it an attractive potential starting point for new antigiardial drugs. View Full-Text
- Supplementary File 1:
Supplementary (ZIP, 1022 KB)
Scifeed alert for new publicationsNever miss any articles matching your research from any publisher
- Get alerts for new papers matching your research
- Find out the new papers from selected authors
- Updated daily for 49'000+ journals and 6000+ publishers
- Define your Scifeed now
Gutiérrez-Gutiérrez, F.; Puebla-Pérez, A.M.; González-Pozos, S.; Hernández-Hernández, J.M.; Pérez-Rangel, A.; Alvarez, L.P.; Tapia-Pastrana, G.; Castillo-Romero, A. Antigiardial Activity of Podophyllotoxin-Type Lignans from Bursera fagaroides var. fagaroides. Molecules 2017, 22, 799.
Gutiérrez-Gutiérrez F, Puebla-Pérez AM, González-Pozos S, Hernández-Hernández JM, Pérez-Rangel A, Alvarez LP, Tapia-Pastrana G, Castillo-Romero A. Antigiardial Activity of Podophyllotoxin-Type Lignans from Bursera fagaroides var. fagaroides. Molecules. 2017; 22(5):799.Chicago/Turabian Style
Gutiérrez-Gutiérrez, Filiberto; Puebla-Pérez, Ana M.; González-Pozos, Sirenia; Hernández-Hernández, José M.; Pérez-Rangel, Armando; Alvarez, Laura P.; Tapia-Pastrana, Gabriela; Castillo-Romero, Araceli. 2017. "Antigiardial Activity of Podophyllotoxin-Type Lignans from Bursera fagaroides var. fagaroides." Molecules 22, no. 5: 799.
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.