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Molecules 2017, 22(5), 782; doi:10.3390/molecules22050782

Mesoporous Silica Nanoparticles as Carriers for Intracellular Delivery of Nucleic Acids and Subsequent Therapeutic Applications

1
Department of General Surgery, Yancheng City No. 1 People’s Hospital, Yancheng 224001, China
2
Department of Medical Oncology, Yancheng City No. 1 People’s Hospital, Yancheng 224001, China
3
Department of Gerontology, Yancheng City No. 1 People’s Hospital, Yancheng 224001, China
4
Department of Clinical Medicine, Nantong University Xinglin College, Nantong 226000, China
5
School of Chemistry and Chemical Engineering, Nanjing Unviersity, Nanjing 210023, China
These authors contributed equally to this work.
*
Authors to whom correspondence should be addressed.
Academic Editors: Jessica Rosenholm and Derek J. McPhee
Received: 13 March 2017 / Revised: 8 May 2017 / Accepted: 9 May 2017 / Published: 11 May 2017
(This article belongs to the Special Issue Mesoporous Silica in Biomedical Applications)
View Full-Text   |   Download PDF [38110 KB, uploaded 11 May 2017]   |  

Abstract

Nucleic acids, including DNA, microRNA (miRNA), small interfering RNA (siRNA), and antisense oligonucleotide (ASO), are powerful gene regulators, which have been demonstrated as promising drug candidates for therapeutic treatments. Nevertheless, poor cellular membrane permeability and serum stability have greatly hindered the applications of nucleic acids in biomedicine. To address these issues, associate carriers that can encapsulate and protect nucleic acids are urgently required. Mesoporous silica nanoparticles (MSNs or MSNPs), which are nanomaterials with excellent biocompatibility, large surface area for functionalization, and tunable pore size for encapsulating different cargos, are emerging as novel and ideal biomaterials for different biomedical applications. In this review paper, we focus on the applications of MSNs in nucleic acid delivery and nucleic acid-guided therapeutic treatments. General strategies for the preparation of nucleic acid-MSN complexes will be firstly introduced, followed by a summary of recent applications of MSNs in nucleic acid delivery and nucleic acid-guided therapeutics. View Full-Text
Keywords: mesoporous silica nanoparticles; nucleic acids; drug delivery; therapeutics mesoporous silica nanoparticles; nucleic acids; drug delivery; therapeutics
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Cha, W.; Fan, R.; Miao, Y.; Zhou, Y.; Qin, C.; Shan, X.; Wan, X.; Li, J. Mesoporous Silica Nanoparticles as Carriers for Intracellular Delivery of Nucleic Acids and Subsequent Therapeutic Applications. Molecules 2017, 22, 782.

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