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Molecules 2017, 22(5), 753; doi:10.3390/molecules22050753

Synthesis of Europium-Doped Fluorapatite Nanorods and Their Biomedical Applications in Drug Delivery

1
Department of Plastic Surgery, Zhejiang Provincial People’s Hospital, People’s Hospital of Hangzhou Medical College, Hangzhou 310014, China
2
State Key Laboratory of Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu 610041, China
3
Department of Biomedical Engineering, College of Engineering, Peking University, Beijing 100871, China
*
Authors to whom correspondence should be addressed.
Academic Editor: Svetlana V. Eliseeva
Received: 5 April 2017 / Revised: 23 April 2017 / Accepted: 4 May 2017 / Published: 6 May 2017
(This article belongs to the Special Issue Lanthanide Luminescence: Fundamental Research and Applications)
View Full-Text   |   Download PDF [2671 KB, uploaded 6 May 2017]   |  

Abstract

Europium (Eu)-doped fluorapatite (FA) nanorods have a biocompatibility similar to that of hydroxyapatite (HA) for use as cell imaging biomaterials due to their luminescent property. Here, we discuss the new application of europium-doped fluorapatite (Eu-FA) nanorods as an anticancer drug carrier. The Eu-FA nanorods were prepared by using a hydrothermal method. The morphology, crystal structure, fluorescence, and composition were investigated. The specific crystal structure enables the effective loading of drug molecules. Doxorubicin (DOX), which was used as a model anticancer drug, effectively loaded onto the surface of the nanorods. The DOX release was pH-dependent and occurred more rapidly at pH 5.5 than at pH 7.4. The intracellular penetration of the DOX-loaded Eu-FA nanorods (Eu-FA/DOX) can be imaged in situ due to the self-fluorescence property. Treatment of melanoma A375 cells with Eu-FA/DOX elicited a more effective apoptosis rate than direct DOX treatment. Overall, Eu-FA exhibits potential for tracking and treating tumors and may be potentially useful as a multifunctional carrier system to effectively load and sustainably deliver drugs. View Full-Text
Keywords: lanthanides; fluorapatite; drug loading; nano carrier lanthanides; fluorapatite; drug loading; nano carrier
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Zeng, H.; Li, X.; Sun, M.; Wu, S.; Chen, H. Synthesis of Europium-Doped Fluorapatite Nanorods and Their Biomedical Applications in Drug Delivery. Molecules 2017, 22, 753.

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