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Molecules 2017, 22(4), 643; doi:10.3390/molecules22040643

An Expedient Total Synthesis of Triciribine

Jiangxi Key Laboratory of Organic Chemistry, Jiangxi Science & Technology Normal University, Nanchang 330013, China
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Academic Editor: Roman Dembinski
Received: 6 March 2017 / Revised: 11 April 2017 / Accepted: 11 April 2017 / Published: 17 April 2017
(This article belongs to the Section Organic Synthesis)
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Abstract

In the present paper, we report an expedient total synthesis of triciribine, a tricyclic 7-deazapurine nucleoside and protein kinase B (AKT ) inhibitor, in 35% overall yield. Our synthesis route features a highly regioselective substitution of 1-N-Boc-2-methylhydrazine and a trifluoroacetic acid catalyzed one-pot transformation which combined the deprotection of the tert-butylcarbonyl (Boc) group and ring closure reaction together to give a tricyclic nucleobase motif. View Full-Text
Keywords: triciribine; ring closure; nucleosides; glycosylation; total synthesis triciribine; ring closure; nucleosides; glycosylation; total synthesis
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Hu, C.; Ruan, Z.; Ding, H.; Zhou, Y.; Xiao, Q. An Expedient Total Synthesis of Triciribine. Molecules 2017, 22, 643.

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