An Expedient Total Synthesis of Triciribine
AbstractIn the present paper, we report an expedient total synthesis of triciribine, a tricyclic 7-deazapurine nucleoside and protein kinase B (AKT ) inhibitor, in 35% overall yield. Our synthesis route features a highly regioselective substitution of 1-N-Boc-2-methylhydrazine and a trifluoroacetic acid catalyzed one-pot transformation which combined the deprotection of the tert-butylcarbonyl (Boc) group and ring closure reaction together to give a tricyclic nucleobase motif. View Full-Text
Scifeed alert for new publicationsNever miss any articles matching your research from any publisher
- Get alerts for new papers matching your research
- Find out the new papers from selected authors
- Updated daily for 49'000+ journals and 6000+ publishers
- Define your Scifeed now
Hu, C.; Ruan, Z.; Ding, H.; Zhou, Y.; Xiao, Q. An Expedient Total Synthesis of Triciribine. Molecules 2017, 22, 643.
Hu C, Ruan Z, Ding H, Zhou Y, Xiao Q. An Expedient Total Synthesis of Triciribine. Molecules. 2017; 22(4):643.Chicago/Turabian Style
Hu, Chen; Ruan, Zhizhong; Ding, Haixin; Zhou, Yirong; Xiao, Qiang. 2017. "An Expedient Total Synthesis of Triciribine." Molecules 22, no. 4: 643.
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.