Establishing Reliable Cu-64 Production Process: From Target Plating to Molecular Specific Tumor Micro-PET Imaging
AbstractCopper-64 is a useful radioisotope for positron emission tomography (PET). Due to the wide range of applications, the demand of 64Cu with low metallic impurities is increasing. Here we report a simple method for the efficient production of high specific activity 64Cu using a cyclotron for biomedical application. We designed new equipment based on the plating of enriched 64Ni as the target, and used automated ion exchange chromatography to purify copper-64 efficiently after irradiation and dissolution of the target in good radiochemical and chemical yield and purity. The 64Cu radionuclide produced using 99.32% enriched 64Ni with a density of 61.4 ± 5.0 mg/cm2, reaching a total radioactivity greater than 200 mCi, with specific activity up to 5.6 GBq/μmoL. It was further incorporated into modified monoclonal antibody DOTA-rituximab to synthesize 64Cu-DOTA-rituximab, which was used successfully for micro-PET imaging. View Full-Text
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Xie, Q.; Zhu, H.; Wang, F.; Meng, X.; Ren, Q.; Xia, C.; Yang, Z. Establishing Reliable Cu-64 Production Process: From Target Plating to Molecular Specific Tumor Micro-PET Imaging. Molecules 2017, 22, 641.
Xie Q, Zhu H, Wang F, Meng X, Ren Q, Xia C, Yang Z. Establishing Reliable Cu-64 Production Process: From Target Plating to Molecular Specific Tumor Micro-PET Imaging. Molecules. 2017; 22(4):641.Chicago/Turabian Style
Xie, Qinghua; Zhu, Hua; Wang, Feng; Meng, Xiangxi; Ren, Qiushi; Xia, Chuanqin; Yang, Zhi. 2017. "Establishing Reliable Cu-64 Production Process: From Target Plating to Molecular Specific Tumor Micro-PET Imaging." Molecules 22, no. 4: 641.
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