Next Article in Journal
Flavonoids: From Structure to Health Issues
Previous Article in Journal
Briarenols C–E, New Polyoxygenated Briaranes from the Octocoral Briareum excavatum
Article Menu
Issue 3 (March) cover image

Export Article

Open AccessArticle
Molecules 2017, 22(3), 461; doi:10.3390/molecules22030461

Pyrrole and Fused Pyrrole Compounds with Bioactivity against Inflammatory Mediators

1
Pharmaceutical Organic Chemistry Department, Faculty of Pharmacy, Helwan University, Ain-Helwan, Helwan 11795, Cairo, Egypt
2
Pharmaceutical Chemistry Department, Faculty of Pharmacy, Helwan University, Ain-Helwan, Helwan 11795, Cairo, Egypt
3
Department of Chemistry and Biochemistry, Concordia University, 7141 rue Sherbrooke O., Montréal, H4Bm1R6 QC, Canada
4
Department of Pharmacology, Faculty of Veterinary Medicine, Cairo University, Giza/Egypt, Giza 12211, Egypt
5
Department of Biochemistry, Faculty of Agriculture, Cairo University, Giza/Egypt, Giza 12211, Egypt
*
Author to whom correspondence should be addressed.
Academic Editor: Diego Muñoz-Torrero
Received: 9 February 2017 / Revised: 3 March 2017 / Accepted: 11 March 2017 / Published: 17 March 2017
(This article belongs to the Section Medicinal Chemistry)
View Full-Text   |   Download PDF [1717 KB, uploaded 17 March 2017]   |  

Abstract

A new series of pyrrolopyridines and pyrrolopyridopyrimidines have been synthesized from aminocyanopyrroles. The synthesized compounds have been characterized by FTIR, 1H-NMR and mass spectroscopy. The final compounds have been screened for in vitro pro-inflammatory cytokine inhibitory and in vivo anti-inflammatory activity. The biological results revealed that among all tested compounds some fused pyrroles, namely the pyrrolopyridines 3i and 3l, show promising activity. A docking study of the active synthesized molecules confirmed the biological results and revealed a new binding pose in the COX-2 binding site. View Full-Text
Keywords: pyrroles; pyrrolopyridines; synthesis; anti-inflammatory assay; cytokine inhibitors; docking study pyrroles; pyrrolopyridines; synthesis; anti-inflammatory assay; cytokine inhibitors; docking study
Figures

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

Scifeed alert for new publications

Never miss any articles matching your research from any publisher
  • Get alerts for new papers matching your research
  • Find out the new papers from selected authors
  • Updated daily for 49'000+ journals and 6000+ publishers
  • Define your Scifeed now

SciFeed Share & Cite This Article

MDPI and ACS Style

Said Fatahala, S.; Hasabelnaby, S.; Goudah, A.; Mahmoud, G.I.; Helmy Abd-El Hameed, R. Pyrrole and Fused Pyrrole Compounds with Bioactivity against Inflammatory Mediators. Molecules 2017, 22, 461.

Show more citation formats Show less citations formats

Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Related Articles

Article Metrics

Article Access Statistics

1

Comments

[Return to top]

Molecules EISSN 1420-3049 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top