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Molecules 2017, 22(3), 451; doi:10.3390/molecules22030451

Chemical Constituents of Smilax china L. Stems and Their Inhibitory Activities against Glycation, Aldose Reductase, α-Glucosidase, and Lipase

Pharmaceutical Botany Laboratory, College of Pharmacy, Chung-Ang University, Heukseok-dong, Dongjak-gu, Seoul 156-756, Korea
These authors contributed equally to this work.
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Author to whom correspondence should be addressed.
Academic Editor: Thomas J. Schmidt
Received: 13 December 2016 / Revised: 7 March 2017 / Accepted: 9 March 2017 / Published: 11 March 2017
(This article belongs to the Section Natural Products)
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Abstract

The search for natural inhibitors with anti-diabetes properties has gained increasing attention. Among four selected Smilacaceae family plants, Smilax china L. stems (SCS) showed significant in vitro anti-glycation and rat lens aldose reductase inhibitory activities. Bioactivity-guided isolation was performed with SCS and four solvent fractions were obtained, which in turn yielded 10 compounds, including one phenolic acid, three chlorogenic acids, four flavonoids, one stilbene, and one phenylpropanoid glycoside; their structures were elucidated using nuclear magnetic resonance and mass spectrometry. All solvent fractions, isolated compounds, and stem extracts from plants sourced from six different provinces of South Korea were next tested for their inhibitory effects against advanced glycation end products, as well as aldose reductase. α-Glucosidase, and lipase assays were also performed on the fractions and compounds. Since compounds 3, 4, 6, and 8 appeared to be the superior inhibitors among the tested compounds, a comparative study was performed via high-performance liquid chromatography with photodiode array detection using a self-developed analysis method to confirm the relationship between the quantity and bioactivity of the compounds in each extract. The findings of this study demonstrate the potent therapeutic efficacy of SCS and its potential use as a cost-effective natural alternative medicine against type 2 diabetes and its complications. View Full-Text
Keywords: Smilax china L.; bioactivity-guided isolation; advanced glycation end products formation inhibitory assay; aldose reductase inhibitory assay; α-glucosidase inhibitory assay; lipase inhibitory assay Smilax china L.; bioactivity-guided isolation; advanced glycation end products formation inhibitory assay; aldose reductase inhibitory assay; α-glucosidase inhibitory assay; lipase inhibitory assay
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

Lee, H.E.; Kim, J.A.; Whang, W.K. Chemical Constituents of Smilax china L. Stems and Their Inhibitory Activities against Glycation, Aldose Reductase, α-Glucosidase, and Lipase. Molecules 2017, 22, 451.

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