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Molecules 2017, 22(3), 358;

Chlorogenic Acid: Recent Advances on Its Dual Role as a Food Additive and a Nutraceutical against Metabolic Syndrome

Tecnológico de Monterrey, Escuela de Ingeniería y Ciencias, Centro de Biotecnología FEMSA, Av. Eugenio Garza Sada 2501 Sur, C.P. 64849 Monterrey, Mexico
Department of Horticultural Sciences, Texas A&M University, College Station, TX 77843-2133, USA
Author to whom correspondence should be addressed.
Received: 19 December 2016 / Revised: 8 February 2017 / Accepted: 21 February 2017 / Published: 26 February 2017
(This article belongs to the Special Issue Recent Advances in Plant Phenolics)
View Full-Text   |   Download PDF [1177 KB, uploaded 28 February 2017]   |  


Chlorogenic acid (5-O-caffeoylquinic acid) is a phenolic compound from the
hydroxycinnamic acid family. This polyphenol possesses many health-promoting properties, most
of them related to the treatment of metabolic syndrome, including anti-oxidant, anti-inflammatory,
antilipidemic, antidiabetic, and antihypertensive activities. The first part of this review will discuss
the role of chlorogenic acid as a nutraceutical for the prevention and treatment of metabolic
syndrome and associated disorders, including in vivo studies, clinical trials, and mechanisms of
action. The second part of the review will be dealing with the role of chlorogenic acid as a food
additive. Chlorogenic acid has shown antimicrobial activity against a wide range of organisms,
including bacteria, yeasts, molds, viruses, and amoebas. These antimicrobial properties can be
useful for the food industry in its constant search for new and natural molecules for the
preservation of food products. In addition, chlorogenic acid has antioxidant activity, particularly
against lipid oxidation; protective properties against degradation of other bioactive compounds
present in food, and prebiotic activity. The combination of these properties makes chlorogenic acid
an excellent candidate for the formulation of dietary supplements and functional foods. View Full-Text
Keywords: chlorogenic acid; 5-O-caffeoylquinic acid; metabolic syndrome; antibiotic; antioxidant;prebiotic chlorogenic acid; 5-O-caffeoylquinic acid; metabolic syndrome; antibiotic; antioxidant;prebiotic

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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Santana-Gálvez, J.; Cisneros-Zevallos, L.; Jacobo-Velázquez, D.A. Chlorogenic Acid: Recent Advances on Its Dual Role as a Food Additive and a Nutraceutical against Metabolic Syndrome. Molecules 2017, 22, 358.

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