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Molecules 2017, 22(2), 309; doi:10.3390/molecules22020309

Ent-Abietanoids Isolated from Isodon serra

1
State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, China
2
Kunming College of Life Sciences, University of Chinese Academy of Sciences, Beijing 100039, China
*
Author to whom correspondence should be addressed.
Academic Editor: Derek J. McPhee
Received: 17 January 2016 / Revised: 13 February 2017 / Accepted: 14 February 2017 / Published: 17 February 2017
(This article belongs to the Special Issue Diterpene and Its Significance in Natural Medicine)
View Full-Text   |   Download PDF [821 KB, uploaded 17 February 2017]   |  

Abstract

Four new ent-abietane diterpenoids, along with four known ones were isolated from the aerial parts of Isodon serra, a traditional Chinese folk medicine. The new diterpenoids were named as serrin K (1), xerophilusin XVII (2), and enanderianins Q and R (3 and 4), while the known ones were identified as rubescansin J (5), (3α,14β)-3,18-[(1-methylethane-1,1-diyl)dioxy]-ent-abieta-7,15(17)-diene-14,16-diol (6), xerophilusin XIV (7), and enanderianin P (8), respectively. Their structures were elucidated by extensive spectroscopic analysis and comparison with the literature. Compound 1 showed remarkable inhibitory activity towards NO production in LPS-stimulated RAW264.7 cells (IC50 = 1.8 μM) and weak cytotoxicity towards five human tumor cell lines (HL-60, SMMC-7721, A-549, MCF-7, SW480). View Full-Text
Keywords: Isodon serra; ent-abietane diterpenoids; anti-inflammation; cytotoxicity Isodon serra; ent-abietane diterpenoids; anti-inflammation; cytotoxicity
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

Wan, J.; Jiang, H.-Y.; Tang, J.-W.; Li, X.-R.; Du, X.; Li, Y.; Sun, H.-D.; Pu, J.-X. Ent-Abietanoids Isolated from Isodon serra. Molecules 2017, 22, 309.

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