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Molecules 2017, 22(2), 299; doi:10.3390/molecules22020299

A Review on the Phytochemistry, Pharmacology, and Pharmacokinetics of Amentoflavone, a Naturally-Occurring Biflavonoid

1
Jiangsu Collaborative Innovation Center of Chinese Medicinal Resources Industrialization, College of Pharmacy, Nanjing University of Chinese Medicine, 138 Xianlin Road, Nanjing 210023, China
2
Department of Chemistry, National University of Singapore, Singapore 117543, Singapore
*
Author to whom correspondence should be addressed.
Academic Editor: Thomas J. Schmidt
Received: 12 January 2017 / Revised: 11 February 2017 / Accepted: 14 February 2017 / Published: 16 February 2017
(This article belongs to the Section Natural Products)
View Full-Text   |   Download PDF [649 KB, uploaded 16 February 2017]   |  

Abstract

Amentoflavone (C30H18O10) is a well-known biflavonoid occurring in many natural plants. This polyphenolic compound has been discovered to have some important bioactivities, including anti-inflammation, anti-oxidation, anti-diabetes, and anti-senescence effects on many important reactions in the cardiovascular and central nervous system, etc. Over 120 plants have been found to contain this bioactive component, such as Selaginellaceae, Cupressaceae, Euphorbiaceae, Podocarpaceae, and Calophyllaceae plant families. This review paper aims to profile amentoflavone on its plant sources, natural derivatives, pharmacology, and pharmacokinetics, and to highlight some existing issues and perspectives in the future. View Full-Text
Keywords: amentoflavone; biflavonoid; natural derivatives; pharmacokinetics; pharmacology; phytochemistry amentoflavone; biflavonoid; natural derivatives; pharmacokinetics; pharmacology; phytochemistry
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Yu, S.; Yan, H.; Zhang, L.; Shan, M.; Chen, P.; Ding, A.; Li, S.F.Y. A Review on the Phytochemistry, Pharmacology, and Pharmacokinetics of Amentoflavone, a Naturally-Occurring Biflavonoid. Molecules 2017, 22, 299.

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