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Molecules 2017, 22(2), 275; doi:10.3390/molecules22020275

Anti-Bacterial and Anti-Fungal Activity of Xanthones Obtained via Semi-Synthetic Modification of α-Mangostin from Garcinia mangostana

1
Asthagiri Herbal Research Foundation, 162A, Perungudi Industrial Estate, Perungudi, Chennai 600096, India
2
Department of Biology, Chemistry and Environmental Sciences, American University of Sharjah, P.O. Box 26666 Sharjah, United Arab Emirates
3
Institute of Sciences of Food Productions, CNR-ISPA, Lecce 73100, Italy
*
Author to whom correspondence should be addressed.
Academic Editors: Daniela Barlocco and Fiorella Meneghetti
Received: 14 December 2016 / Revised: 7 February 2017 / Accepted: 8 February 2017 / Published: 12 February 2017
(This article belongs to the Special Issue Frontiers in Antimicrobial Drug Discovery and Design)
View Full-Text   |   Download PDF [3248 KB, uploaded 12 February 2017]   |  

Abstract

The microbial contamination in food packaging has been a major concern that has paved the way to search for novel, natural anti-microbial agents, such as modified α-mangostin. In the present study, twelve synthetic analogs were obtained through semi-synthetic modification of α-mangostin by Ritter reaction, reduction by palladium-carbon (Pd-C), alkylation, and acetylation. The evaluation of the anti-microbial potential of the synthetic analogs showed higher bactericidal activity than the parent molecule. The anti-microbial studies proved that I E showed high anti-bacterial activity whereas I I showed the highest anti-fungal activity. Due to their microbicidal potential, modified α-mangostin derivatives could be utilized as active anti-microbial agents in materials for the biomedical and food industry. View Full-Text
Keywords: α-mangostin; anti-bacterial; anti-fungal; packaging; textiles; biomedical device; semi-synthetic modification α-mangostin; anti-bacterial; anti-fungal; packaging; textiles; biomedical device; semi-synthetic modification
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

Narasimhan, S.; Maheshwaran, S.; Abu-Yousef, I.A.; Majdalawieh, A.F.; Rethavathi, J.; Das, P.E.; Poltronieri, P. Anti-Bacterial and Anti-Fungal Activity of Xanthones Obtained via Semi-Synthetic Modification of α-Mangostin from Garcinia mangostana. Molecules 2017, 22, 275.

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