Next Article in Journal
Construction and Biological Evaluation of a Novel Integrin ανβ3-Specific Carrier for Targeted siRNA Delivery In Vitro
Next Article in Special Issue
Preparation of Photoirradiation Molecular Imprinting Polymer for Selective Separation of Branched Cyclodextrins
Previous Article in Journal
Synthesis of Novel Pyrazinamide Derivatives Based on 3-Chloropyrazine-2-carboxamide and Their Antimicrobial Evaluation
Previous Article in Special Issue
Transition Metal Complexes Coordinated by Water Soluble Phosphane Ligands: How Cyclodextrins Can Alter the Coordination Sphere?
Article Menu
Issue 2 (February) cover image

Export Article

Open AccessReview
Molecules 2017, 22(2), 230; doi:10.3390/molecules22020230

Electrospun Fibers of Cyclodextrins and Poly(cyclodextrins)

Departamento de Farmacología, Farmacia y Tecnología Farmacéutica, R+D Pharma Group (GI-1645), Facultad de Farmacia and Health Research Institute of Santiago de Compostela (IDIS), Universidade de Santiago de Compostela, 15872 Santiago de Compostela, Spain
*
Author to whom correspondence should be addressed.
Academic Editor: Bernard Martel
Received: 6 December 2016 / Revised: 21 January 2017 / Accepted: 30 January 2017 / Published: 3 February 2017
(This article belongs to the Special Issue Cyclodextrin Chemistry)
View Full-Text   |   Download PDF [2768 KB, uploaded 3 February 2017]   |  

Abstract

Cyclodextrins (CDs) can endow electrospun fibers with outstanding performance characteristics that rely on their ability to form inclusion complexes. The inclusion complexes can be blended with electrospinnable polymers or used themselves as main components of electrospun nanofibers. In general, the presence of CDs promotes drug release in aqueous media, but they may also play other roles such as protection of the drug against adverse agents during and after electrospinning, and retention of volatile fragrances or therapeutic agents to be slowly released to the environment. Moreover, fibers prepared with empty CDs appear particularly suitable for affinity separation. The interest for CD-containing nanofibers is exponentially increasing as the scope of applications is widening. The aim of this review is to provide an overview of the state-of-the-art on CD-containing electrospun mats. The information has been classified into three main sections: (i) fibers of mixtures of CDs and polymers, including polypseudorotaxanes and post-functionalization; (ii) fibers of polymer-free CDs; and (iii) fibers of CD-based polymers (namely, polycyclodextrins). Processing conditions and applications are analyzed, including possibilities of development of stimuli-responsive fibers. View Full-Text
Keywords: electrospinning; cyclodextrin; polycyclodextrin; nanofiber; polypseudorotaxane; controlled release; regenerative medicine; filtration membrane; stimulus-responsive fiber; post-processing; fast dissolving amorphous products electrospinning; cyclodextrin; polycyclodextrin; nanofiber; polypseudorotaxane; controlled release; regenerative medicine; filtration membrane; stimulus-responsive fiber; post-processing; fast dissolving amorphous products
Figures

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

Scifeed alert for new publications

Never miss any articles matching your research from any publisher
  • Get alerts for new papers matching your research
  • Find out the new papers from selected authors
  • Updated daily for 49'000+ journals and 6000+ publishers
  • Define your Scifeed now

SciFeed Share & Cite This Article

MDPI and ACS Style

Costoya, A.; Concheiro, A.; Alvarez-Lorenzo, C. Electrospun Fibers of Cyclodextrins and Poly(cyclodextrins). Molecules 2017, 22, 230.

Show more citation formats Show less citations formats

Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Related Articles

Article Metrics

Article Access Statistics

1

Comments

[Return to top]

Molecules EISSN 1420-3049 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top