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Molecules 2017, 22(2), 153; doi:10.3390/molecules22020153

Synthesis, Characterization and Antibacterial Studies of N-(Benzothiazol-2-yl)-4-chlorobenzenesulphonamide and Its Neodymium(III) and Thallium(III) Complexes

1
Department of Pure and Industrial Chemistry, University of Nigeria, Nsukka 410001, Nigeria
2
Department of Pharmaceutical Chemistry, College of Pharmacy, King Saud University, P.O. Box 2457, Riyadh 11451, Saudi Arabia
3
Computational Chemistry Group, Department of Chemistry, Faculty of Science, University of Mauritius, Réduit 80837, Mauritius
4
Department of Applied Chemistry, University of Johannesburg, Doornfontein Campus, Johannesburg 2028, South Africa
*
Author to whom correspondence should be addressed.
Academic Editors: Panayiotis A. Koutentis and Andreas S. Kalogirou
Received: 9 November 2016 / Revised: 4 January 2017 / Accepted: 4 January 2017 / Published: 22 February 2017
(This article belongs to the Special Issue Sulfur-Nitrogen Heteroaromatics)
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Abstract

N-(Benzothiazol-2-yl)-4-chlorobenzenesulphonamide (NBTCS) was synthesized by condensation reaction of 4-chlorobenzenesulphonyl chloride and 2-aminobenzothiazole in acetone under reflux. Neodymium(III) and thallium(III) complexes of the ligand were also synthesized. Both ligand and metal complexes were characterized using UV-Vis, IR, 1H- and 13C-NMR spectroscopies, elemental analysis and molar conductance measurement. IR studies revealed that the ligand is tridentate and coordinates to the metal ions through nitrogen and oxygen atoms of the sulphonamide group and nitrogen atom attached to benzothiazole ring. The neodymium(III) complex displays a coordination number of eight while thallium(III) complex displays a coordination number of six. The ligand and its complexes were screened in vitro for their antibacterial activities against Escherichia coli strains (E. coli 6 and E. coli 13), Proteus species, Staphylococcus aureus and Pseudomonas aeruginosa using the agar well diffusion technique. The synthesized compounds were found to be more active against the microorganisms screened relative to ciprofloxacin, gentamicin and co-trimoxazole. View Full-Text
Keywords: N-(benzothiazol-2-yl)-4-chlorobenzenesulphonamide; neodymium(III) and thallium(III) complexes; antibacterial activity N-(benzothiazol-2-yl)-4-chlorobenzenesulphonamide; neodymium(III) and thallium(III) complexes; antibacterial activity
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MDPI and ACS Style

Obasi, L.N.; Oruma, U.S.; Al-Swaidan, I.A.; Ramasami, P.; Ezeorah, C.J.; Ochonogor, A.E. Synthesis, Characterization and Antibacterial Studies of N-(Benzothiazol-2-yl)-4-chlorobenzenesulphonamide and Its Neodymium(III) and Thallium(III) Complexes. Molecules 2017, 22, 153.

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