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Molecules 2017, 22(12), 2083; doi:10.3390/molecules22122083

Lipoprotein Lipase Expression in Chronic Lymphocytic Leukemia: New Insights into Leukemic Progression

1
Department of Developmental Neurobiology, Instituto de Investigaciones Biologicas Clemente Estable, 11400 Montevideo, Uruguay
2
Research Laboratory on Chronic Lymphocytic Leukemia, Institut Pasteur de Montevideo, 11400 Montevideo, Uruguay
*
Author to whom correspondence should be addressed.
Received: 3 October 2017 / Revised: 24 November 2017 / Accepted: 24 November 2017 / Published: 5 December 2017
(This article belongs to the Special Issue Lipases and Lipases Modification)
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Abstract

Lipoprotein lipase (LPL) is a central enzyme in lipid metabolism. Due to its catalytic activity, LPL is involved in metabolic pathways exploited by various solid and hematologic malignancies to provide an extra energy source to the tumor cell. We and others described a link between the expression of LPL in the tumor cell and a poor clinical outcome of patients suffering Chronic Lymphocytic Leukemia (CLL). This leukemia is characterized by a slow accumulation of mainly quiescent clonal CD5 positive B cells that infiltrates secondary lymphoid organs, bone marrow and peripheral blood. Despite LPL being found to be a reliable molecular marker for CLL prognosis, its functional role and the molecular mechanisms regulating its expression are still matter of debate. Herein we address some of these questions reviewing the current state of the art of LPL research in CLL and providing some insights into where currently unexplored questions may lead to. View Full-Text
Keywords: lipoprotein lipase; chronic lymphocytic leukemia; cancer; prognostic markers lipoprotein lipase; chronic lymphocytic leukemia; cancer; prognostic markers
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Prieto, D.; Oppezzo, P. Lipoprotein Lipase Expression in Chronic Lymphocytic Leukemia: New Insights into Leukemic Progression. Molecules 2017, 22, 2083.

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