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Molecules 2017, 22(12), 1868; https://doi.org/10.3390/molecules22121868

Studies on the Anti-Oxidative Function of trans-Cinnamaldehyde-Included β-Cyclodextrin Complex

1
Department of Food Science and Technology, Chung-ang University, Gyeonggi-do 17546, Korea
2
Institute of Process Engineering in Life Science, Section I: Food Process Engineering, Karlsruhe Institute of Technology, 76131 Karlsruhe, Germany
3
Department of Food Science and Biotechnology, Sejong University, 209 Neungdong-ro, Seoul 05006, Korea
4
Division of Metabolism and Functionality Research, Korea Food Research Institute, 1201-62 Anyangpangyo-ro, Bundang-gu, Seongnam-si, Gyeonggi-do 13539, Korea
5
Department of Food Science and Biotechnology of Animal Resources, Konkuk University, 120 Neungdong-ro, Seoul 05029, Korea
These authors contributed equally to this article.
*
Authors to whom correspondence should be addressed.
Received: 31 October 2017 / Revised: 4 December 2017 / Accepted: 16 December 2017 / Published: 19 December 2017
(This article belongs to the Special Issue Extractable and Non-Extractable Antioxidants)
View Full-Text   |   Download PDF [1950 KB, uploaded 19 December 2017]   |  

Abstract

trans-Cinnamaldehyde (tCIN), an active compound found in cinnamon, is well known for its antioxidant, anticancer, and anti-inflammatory activities. The β-cyclodextrin (β-CD) oligomer has been used for a variety of applications in nanotechnology, including pharmaceutical and cosmetic applications. Here, we aimed to evaluate the anti-inflammatory and antioxidant effects of tCIN self-included in β-CD complexes (CIs) in lipopolysaccharide (LPS)-treated murine RAW 264.7 macrophages. RAW 264.7 macrophages were treated with increasing concentrations of β-CD, tCIN, or CIs for different times. β-CD alone did not affect the production of nitric oxide (NO) or reactive oxygen species (ROS). However, both tCIN and CI significantly reduced NO and ROS production. Thus, CIs may have strong anti-inflammatory and antioxidant effects, similar to those of tCIN when used alone. View Full-Text
Keywords: trans-cinnamaldehyde; β-cyclodextrin; self-inclusion; anti-inflammation; antioxidant trans-cinnamaldehyde; β-cyclodextrin; self-inclusion; anti-inflammation; antioxidant
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Davaatseren, M.; Jo, Y.-J.; Hong, G.-P.; Hur, H.J.; Park, S.; Choi, M.-J. Studies on the Anti-Oxidative Function of trans-Cinnamaldehyde-Included β-Cyclodextrin Complex. Molecules 2017, 22, 1868.

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