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Molecules 2017, 22(12), 2268; doi:10.3390/molecules22122268

Quinoline-Based Hybrid Compounds with Antimalarial Activity

Department of Chemistry, University of Fort Hare, Alice Campus, Alice 5700, Eastern Cape, South Africa
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Received: 7 November 2017 / Revised: 11 December 2017 / Accepted: 11 December 2017 / Published: 19 December 2017
(This article belongs to the Special Issue Emerging Drug Discovery Approaches against Infectious Diseases)
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Abstract

The application of quinoline-based compounds for the treatment of malaria infections is hampered by drug resistance. Drug resistance has led to the combination of quinolines with other classes of antimalarials resulting in enhanced therapeutic outcomes. However, the combination of antimalarials is limited by drug-drug interactions. In order to overcome the aforementioned factors, several researchers have reported hybrid compounds prepared by reacting quinoline-based compounds with other compounds via selected functionalities. This review will focus on the currently reported quinoline-based hybrid compounds and their preclinical studies. View Full-Text
Keywords: 4-aminoquinoline; 8-aminoquinoline; malaria; infectious disease; hybrid compound 4-aminoquinoline; 8-aminoquinoline; malaria; infectious disease; hybrid compound
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Nqoro, X.; Tobeka, N.; Aderibigbe, B.A. Quinoline-Based Hybrid Compounds with Antimalarial Activity. Molecules 2017, 22, 2268.

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