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Molecules 2017, 22(11), 1932; doi:10.3390/molecules22111932

Anticancer and Immunogenic Properties of Cardiac Glycosides

1
Programa de Pós-Graduação em Farmácia, Centro de Ciências da Saúde, Universidade Federal de Santa Catarina, Florianópolis, SC 88040-900, Brazil
2
Laboratoire de Biologie Moléculaire et Cellulaire du Cancer (LBMCC), Hôpital Kirchberg, 9, rue Edward Steichen, 2540 Luxembourg, Luxembourg
3
Department of Pharmacy, Research Institute of Pharmaceutical Sciences, College of Pharmacy, Seoul National University, Building 29 Room 223, 1 Gwanak-ro, Gwanak-gu 08826, Korea
*
Author to whom correspondence should be addressed.
Received: 5 October 2017 / Revised: 29 October 2017 / Accepted: 4 November 2017 / Published: 8 November 2017
(This article belongs to the Special Issue Cardiotonic Steroids)
View Full-Text   |   Download PDF [1449 KB, uploaded 9 November 2017]   |  

Abstract

Cardiac glycosides (CGs) are natural compounds widely used in the treatment of several cardiac conditions and more recently have been recognized as potential antitumor compounds. They are known to be ligands for Na/K-ATPase, which is a promising drug target in cancer. More recently, in addition to their antitumor effects, it has been suggested that CGs activate tumor-specific immune responses. This review summarizes the anticancer aspects of CGs as new strategies for immunotherapy and drug repositioning (new horizons for old players), and the possible new targets for CGs in cancer cells. View Full-Text
Keywords: cardiac glycosides; anticancer; immunogenic cell death; cytotoxic effects; cancer cells; Na/K-ATPase cardiac glycosides; anticancer; immunogenic cell death; cytotoxic effects; cancer cells; Na/K-ATPase
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Schneider, N.F.Z.; Cerella, C.; Simões, C.M.O.; Diederich, M. Anticancer and Immunogenic Properties of Cardiac Glycosides. Molecules 2017, 22, 1932.

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