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Molecules 2017, 22(10), 1778; doi:10.3390/molecules22101778

Rapid Classification and Identification of Chemical Components of Schisandra Chinensis by UPLC-Q-TOF/MS Combined with Data Post-Processing

Tianjin State Key Laboratory of Modern Chinese Medicine, School of Traditional Chinese Materia Medica, Tianjin University of Traditional Chinese Medicine, 312 Anshan West Road, Tianjin 300193, China
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Received: 13 September 2017 / Revised: 15 October 2017 / Accepted: 17 October 2017 / Published: 20 October 2017
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Abstract

Schisandra chinensis (known in Chinese as WuWeiZi, WWZ) has observable effects such as astringing the lung to stop coughs, arresting sweating, preserving semen and preventing diarrhea. The major components of WWZ include lignans, triterpenoids, organic acids and fatty acids. In this paper, a reliable method for the rapid identification of multiple components in WWZ by their characteristic fragments and neutral losses using UPLC-Q-TOF/MS technology was developed. After review of the literature and some reference experiments, the fragmentation pattern of several compounds were studied and summarized. Then, according to the corresponding characteristic fragments coupled with neutral losses in the positive or negative ion mode produced by different types of substances a rapid identification of target compounds was achieved. Finally, a total of 30 constituents of WWZ were successfully identified, including 15 lignans, nine triterpenoids, three organic acids and three fatty acids. The method established in this study not only provides a comprehensive analysis of the chemical ingredients of WWZ, providing a basis for further phytochemical studies on WWZ but also provides a more efficient way to solve the problem of identification of complex chemical constituents in traditional Chinese medicines. View Full-Text
Keywords: WuWeiZi(WWZ); UPLC-Q-TOF/MS; characteristic fragments (CFs); neutral losses (NLs) WuWeiZi(WWZ); UPLC-Q-TOF/MS; characteristic fragments (CFs); neutral losses (NLs)
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MDPI and ACS Style

Yang, S.; Shan, L.; Luo, H.; Sheng, X.; Du, J.; Li, Y. Rapid Classification and Identification of Chemical Components of Schisandra Chinensis by UPLC-Q-TOF/MS Combined with Data Post-Processing. Molecules 2017, 22, 1778.

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