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Molecules 2017, 22(10), 1751; doi:10.3390/molecules22101751

New Cassane Diterpenoids from Caesalpinia sappan and their Antiplasmodial Activity

1
Key Laboratory of Bioactive Substances and Resource Utilization of Chinese Herbal Medicine, Ministry of Education, Beijing Key Laboratory of Innovative Drug Discovery of Traditional Chinese Medicine (Natural Medicine) and Translational Medicine, Key Laboratory of Efficacy Evaluation of Chinese Medicine against Glycolipid Metabolic Disorders, State Administration of Traditional Chinese Medicine, Institute of Medicinal Plant Development, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing 100193, China
2
Center of Research and Development on Life Sciences and Environment Sciences, Harbin University of Commerce, Harbin 150076, China
3
College of chemistry and materials science, Guangxi Teachers Education University, Nanning 530001, China
These authors contributed equally to this work.
*
Authors to whom correspondence should be addressed.
Received: 24 August 2017 / Revised: 13 October 2017 / Accepted: 13 October 2017 / Published: 17 October 2017
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Abstract

One new cassane diterpene possessing an unusual N bridge between C-19 and C-20 named caesalsappanin R (1), as well as another new diterpene caesalsappanin S (2), were isolated from the seeds of Caesalpinia sappanwith methanol extract. Their structures were determined by spectroscopic analysis and examined alongside existing data from prior studies. Their biological activities were profiled by their antiplasmodial activity. View Full-Text
Keywords: Caesalpinia sappan; cassane diterpenes; N bridge; antiplasmodial activity Caesalpinia sappan; cassane diterpenes; N bridge; antiplasmodial activity
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Zhu, N.-L.; Sun, Z.-H.; Hu, M.-G.; Wu, T.-Y.; Yuan, J.-Q.; Wu, H.-F.; Tian, Y.; Li, P.-F.; Yang, J.-S.; Ma, G.-X.; Xu, X.-D. New Cassane Diterpenoids from Caesalpinia sappan and their Antiplasmodial Activity. Molecules 2017, 22, 1751.

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