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Molecules 2017, 22(10), 1670;

Phaseolus acutifolius Lectin Fractions Exhibit Apoptotic Effects on Colon Cancer: Preclinical Studies Using Dimethilhydrazine or Azoxi-Methane as Cancer Induction Agents

Facultad de Ciencias Naturales, Universidad Autónoma de Querétaro, Av. de las Ciencias s/n. Juriquilla, CP 76230 Querétaro, Mexico
Depto de Biotecnología y Bioquímica, CINVESTAV-Unidad Irapuato, Guanajuato CP 36821, Mexico
Universidad Autónoma de Querétaro, Querétaro CP 76176, Mexico
Ulisses Moreno-Celis and Josué López-Martínez share the first authorship.
Authors to whom correspondence should be addressed.
Received: 24 August 2017 / Revised: 28 September 2017 / Accepted: 28 September 2017 / Published: 8 October 2017
(This article belongs to the Collection Natural Products: Anticancer Potential and Beyond)
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Phaseolus acutifolius (Tepary bean) lectins have been studied as cytotoxic molecules on colon cancer cells. The toxicological profile of a Tepary bean lectin fraction (TBLF) has shown low toxicity in experimental animals; exhibiting anti-nutritional effects such as a reduction in body weight gain and a decrease in food intake when using a dose of 50 mg/kg on alternate days for six weeks. Taking this information into account, the focus of this work was to evaluate the effect of the TBLF on colon cancer using 1,2-dimethylhydrazine (DMH) or azoxy-methane/dextran sodium sulfate (AOM/DSS) as colon cancer inductors. Rats were treated with DMH or AOM/DSS and then administered with TBFL (50 mg/kg) for six weeks. TBLF significantly decreased early tumorigenesis triggered by DMH by 70%, but without any evidence of an apoptotic effect. In an independent experiment, AOM/DSS was used to generate aberrant cryptic foci, which decreased by 50% after TBLF treatment. TBLF exhibited antiproliferative and proapoptotic effects related to a decrease of the signal transduction pathway protein Akt in its activated form and an increase of caspase 3 activity, but not to p53 activation. Further studies will deepen our knowledge of specific apoptosis pathways and cellular stress processes such as oxidative damage. View Full-Text
Keywords: colon cancer; apoptosis; lectins; Tepary bean; Phaseolus acutifolius colon cancer; apoptosis; lectins; Tepary bean; Phaseolus acutifolius

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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Moreno-Celis, U.; López-Martínez, J.; Blanco-Labra, A.; Cervantes-Jiménez, R.; Estrada-Martínez, L.E.; García-Pascalin, A.E.; Guerrero-Carrillo, M.D.J.; Rodríguez-Méndez, A.J.; Mejía, C.; Ferríz-Martínez, R.A.; García-Gasca, T. Phaseolus acutifolius Lectin Fractions Exhibit Apoptotic Effects on Colon Cancer: Preclinical Studies Using Dimethilhydrazine or Azoxi-Methane as Cancer Induction Agents. Molecules 2017, 22, 1670.

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