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Molecules 2017, 22(10), 1670; doi:10.3390/molecules22101670

Phaseolus acutifolius Lectin Fractions Exhibit Apoptotic Effects on Colon Cancer: Preclinical Studies Using Dimethilhydrazine or Azoxi-Methane as Cancer Induction Agents

1
Facultad de Ciencias Naturales, Universidad Autónoma de Querétaro, Av. de las Ciencias s/n. Juriquilla, CP 76230 Querétaro, Mexico
2
Depto de Biotecnología y Bioquímica, CINVESTAV-Unidad Irapuato, Guanajuato CP 36821, Mexico
3
Universidad Autónoma de Querétaro, Querétaro CP 76176, Mexico
Ulisses Moreno-Celis and Josué López-Martínez share the first authorship.
*
Authors to whom correspondence should be addressed.
Received: 24 August 2017 / Revised: 28 September 2017 / Accepted: 28 September 2017 / Published: 8 October 2017
(This article belongs to the Special Issue Natural Products: Anticancer Potential and Beyond)
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Abstract

Phaseolus acutifolius (Tepary bean) lectins have been studied as cytotoxic molecules on colon cancer cells. The toxicological profile of a Tepary bean lectin fraction (TBLF) has shown low toxicity in experimental animals; exhibiting anti-nutritional effects such as a reduction in body weight gain and a decrease in food intake when using a dose of 50 mg/kg on alternate days for six weeks. Taking this information into account, the focus of this work was to evaluate the effect of the TBLF on colon cancer using 1,2-dimethylhydrazine (DMH) or azoxy-methane/dextran sodium sulfate (AOM/DSS) as colon cancer inductors. Rats were treated with DMH or AOM/DSS and then administered with TBFL (50 mg/kg) for six weeks. TBLF significantly decreased early tumorigenesis triggered by DMH by 70%, but without any evidence of an apoptotic effect. In an independent experiment, AOM/DSS was used to generate aberrant cryptic foci, which decreased by 50% after TBLF treatment. TBLF exhibited antiproliferative and proapoptotic effects related to a decrease of the signal transduction pathway protein Akt in its activated form and an increase of caspase 3 activity, but not to p53 activation. Further studies will deepen our knowledge of specific apoptosis pathways and cellular stress processes such as oxidative damage. View Full-Text
Keywords: colon cancer; apoptosis; lectins; Tepary bean; Phaseolus acutifolius colon cancer; apoptosis; lectins; Tepary bean; Phaseolus acutifolius
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Moreno-Celis, U.; López-Martínez, J.; Blanco-Labra, A.; Cervantes-Jiménez, R.; Estrada-Martínez, L.E.; García-Pascalin, A.E.; Guerrero-Carrillo, M.D.J.; Rodríguez-Méndez, A.J.; Mejía, C.; Ferríz-Martínez, R.A.; García-Gasca, T. Phaseolus acutifolius Lectin Fractions Exhibit Apoptotic Effects on Colon Cancer: Preclinical Studies Using Dimethilhydrazine or Azoxi-Methane as Cancer Induction Agents. Molecules 2017, 22, 1670.

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