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Molecules 2017, 22(10), 1636; doi:10.3390/molecules22101636

Non-Covalent Organocatalyzed Domino Reactions Involving Oxindoles: Recent Advances

Dipartimento di Scienze, Sezione di Nanoscienze e Nanotecnologie, Università degli Studi Roma Tre, via della Vasca Navale 79, I-00146 Roma, Italy
ICGM-Institut Charles Gerhardt Montpellier, UMR 5253 CNRS-UM-ENSCM, Ecole Nationale Supérieure de Chimie, 8, Rue de l’Ecole Normale, 34296 Montpellier CEDEX 5, France
Authors to whom correspondence should be addressed.
Received: 16 September 2017 / Revised: 25 September 2017 / Accepted: 26 September 2017 / Published: 29 September 2017
(This article belongs to the Collection Recent Advances in Organocatalysis)


The ubiquitous presence of spirooxindole architectures with several functionalities and stereogenic centers in bioactive molecules has been appealing for the development of novel methodologies seeking their preparation in high yields and selectivities. Expansion and refinement in the field of asymmetric organocatalysis have made possible the development of straightforward strategies that address these two requisites. In this review, we illustrate the current state-of-the-art in the field of spirooxindole synthesis through the use of non-covalent organocatalysis. We aim to provide a concise overview of very recent methods that allow to the isolation of unique, densely and diversified spirocyclic oxindole derivatives with high structural diversity via the use of cascade, tandem and domino processes. View Full-Text
Keywords: spirooxindole derivatives; non-covalent organocatalysis; hydrogen-bonding; cascade; tandem; domino; enantioselectivity; chiral building blocks spirooxindole derivatives; non-covalent organocatalysis; hydrogen-bonding; cascade; tandem; domino; enantioselectivity; chiral building blocks

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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

Gasperi, T.; Miceli, M.; Campagne, J.-M.; Marcia de Figueiredo, R. Non-Covalent Organocatalyzed Domino Reactions Involving Oxindoles: Recent Advances. Molecules 2017, 22, 1636.

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