Investigation of the N-Terminus Amino Function of Arg10-Teixobactin
AbstractTeixobactin is a recently described antimicrobial peptide that shows high activity against gram-positive bacteria as well as mycobacterium tuberculosis. Due to both its structure as a head-to-side chain cyclodepsipeptide and its activity, it has attracted the attention of several research groups. In this regard, a large number of analogs with substitutions in both the cycle and the tail has been described. Here, we report the contribution of the N-terminus residue, N-Me-d-Phe, to the activity of Arg10-teixobactin. On the basis of our findings, we conclude that the N-terminus accepts minimum changes but not the presence of long alkyl chains. The presence of a positive charge is a requirement for the activity of the peptide. Furthermore, acylation of the N-terminus leads to total loss of activity. View Full-Text
- Supplementary File 1:
Supplementary (PDF, 2222 KB)
Share & Cite This Article
Monaim, S.A.H.A.; Noki, S.; Ramchuran, E.J.; El-Faham, A.; Albericio, F.; Torre, B.G. Investigation of the N-Terminus Amino Function of Arg10-Teixobactin. Molecules 2017, 22, 1632.
Monaim SAHA, Noki S, Ramchuran EJ, El-Faham A, Albericio F, Torre BG. Investigation of the N-Terminus Amino Function of Arg10-Teixobactin. Molecules. 2017; 22(10):1632.Chicago/Turabian Style
Monaim, Shimaa A. H. Abdel; Noki, Sikabwe; Ramchuran, Estelle J.; El-Faham, Ayman; Albericio, Fernando; Torre, Beatriz G. de la. 2017. "Investigation of the N-Terminus Amino Function of Arg10-Teixobactin." Molecules 22, no. 10: 1632.
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.