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Molecules 2017, 22(1), 90; doi:10.3390/molecules22010090

Effect of Phenolic Compounds from Elderflowers on Glucose- and Fatty Acid Uptake in Human Myotubes and HepG2-Cells

1
Department of Pharmaceutical Chemistry, School of Pharmacy, University of Oslo, P.O. Box 1068 Blindern, 0316 Oslo, Norway
2
Department of Pharmaceutical Biosciences, School of Pharmacy, University of Oslo, P.O. Box 1068 Blindern, 0316 Oslo, Norway
*
Author to whom correspondence should be addressed.
Academic Editors: Atanas G. Atanasov, Karel Šmejkal and Elke Heiss
Received: 31 October 2016 / Revised: 19 December 2016 / Accepted: 29 December 2016 / Published: 6 January 2017
(This article belongs to the Special Issue Effects of Natural Products in the Context of Cardiometabolic Disease)
View Full-Text   |   Download PDF [3643 KB, uploaded 6 January 2017]   |  

Abstract

Type 2 diabetes (T2D) is manifested by progressive metabolic impairments in tissues such as skeletal muscle and liver, and these tissues become less responsive to insulin, leading to hyperglycemia. In the present study, stimulation of glucose and oleic acid uptake by elderflower extracts, constituents and metabolites were tested in vitro using the HepG2 hepatocellular liver carcinoma cell line and human skeletal muscle cells. Among the crude extracts, the 96% EtOH extract showed the highest increase in glucose and oleic acid uptake in human skeletal muscle cells and HepG2-cells. The flavonoids and phenolic acids contained therein were potent stimulators of glucose and fatty acid uptake in a dose-dependent manner. Most of the phenolic constituents and several of the metabolites showed high antioxidant activity and showed considerably higher α-amylase and α-glucosidase inhibition than acarbose. Elderflower might therefore be valuable as a functional food against diabetes. View Full-Text
Keywords: elderflower; Sambucus nigra; type 2 diabetes; human skeletal muscle; HepG2-cell; metabolic disorder; antioxidant; glucose uptake; oleic acid uptake elderflower; Sambucus nigra; type 2 diabetes; human skeletal muscle; HepG2-cell; metabolic disorder; antioxidant; glucose uptake; oleic acid uptake
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

Ho, G.T.T.; Kase, E.T.; Wangensteen, H.; Barsett, H. Effect of Phenolic Compounds from Elderflowers on Glucose- and Fatty Acid Uptake in Human Myotubes and HepG2-Cells. Molecules 2017, 22, 90.

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