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Molecules 2017, 22(1), 176; doi:10.3390/molecules22010176

Research Advances and Detection Methodologies for Microbe-Derived Acetylcholinesterase Inhibitors: A Systemic Review

1,2,3
,
1,2,3
,
1,2,3
,
4
,
3
and
1,2,3,*
1
Fujian Key Laboratory of Innate Immune Biology, Fujian Normal University, Fuzhou 350117, China
2
Biomedical Research Center of South China, Fujian Normal University, Fuzhou 350117, China
3
College of Life Science, Fujian Normal University, Fuzhou 350117, China
4
Tumor Invasion Microecological Laboratory, the First Affiliated Hospital of Fujian Medical University, Fuzhou 350005, China
*
Author to whom correspondence should be addressed.
Academic Editor: Derek J. McPhee
Received: 9 December 2016 / Revised: 11 January 2017 / Accepted: 16 January 2017 / Published: 23 January 2017
View Full-Text   |   Download PDF [8037 KB, uploaded 23 January 2017]   |  

Abstract

Acetylcholinesterase inhibitors (AChEIs) are an attractive research subject owing to their potential applications in the treatment of neurodegenerative diseases. Fungi and bacteria are major producers of AChEIs. Their active ingredients of fermentation products include alkaloids, terpenoids, phenylpropanoids, and steroids. A variety of in vitro acetylcholinesterase inhibitor assays have been developed and used to measure the activity of acetylcholinesterases, including modified Ellman’s method, thin layer chromatography bioautography, and the combined liquid chromatography-mass spectrometry/modified Ellman’s method. In this review, we provide an overview of the different detection methodologies, the microbe-derived AChEIs, and their producing strains. View Full-Text
Keywords: Alzheimer’s disease; acetylcholinesterase inhibitors; in vitro assays Alzheimer’s disease; acetylcholinesterase inhibitors; in vitro assays
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Su, J.; Liu, H.; Guo, K.; Chen, L.; Yang, M.; Chen, Q. Research Advances and Detection Methodologies for Microbe-Derived Acetylcholinesterase Inhibitors: A Systemic Review. Molecules 2017, 22, 176.

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