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Molecules 2017, 22(1), 15; doi:10.3390/molecules22010015

Cinnamaldehyde Ameliorates Cadmium-Inhibited Root Elongation in Tobacco Seedlings via Decreasing Endogenous Hydrogen Sulfide Production

1
Tobacco Science College/National Tobacco Cultivation and Physiology and Biochemistry Research Centre/Key Laboratory for Tobacco Cultivation of Tobacco Industry, Henan Agricultural University, Zhengzhou 450002, China
2
Nanjing Yangzi Modern Agriculture Investment and Development Co. Ltd., Nanjing 211899, China
3
Chongqing Tobacco Corporation, Chongqing 400023, China
4
Hongyun Honghe Tobacco Group Co. Ltd., Kunming 650231, China
5
Henan Tobacco Corporation Queshan Branch, Queshan 463200, China
6
Department of Food Science, Henan Institute of Science and Technology, Xinxiang 453003, China
7
Institute of Food Quality and Safety, Jiangsu Academy of Agricultural Sciences, Nanjing 210014, China
8
Key Lab of Food Quality and Safety of Jiangsu Province-State Key Laboratory Breeding Base, Nanjing 210014, China
These authors contribute equally to this work.
*
Authors to whom correspondence should be addressed.
Academic Editor: Derek J. McPhee
Received: 31 October 2016 / Revised: 13 December 2016 / Accepted: 22 December 2016 / Published: 24 December 2016
(This article belongs to the Section Natural Products)
View Full-Text   |   Download PDF [6967 KB, uploaded 24 December 2016]   |  

Abstract

Cinnamaldehyde (CA) is natural plant-derived compound that has been highly appreciated for its medicinal properties. However, little information is known about the regulation of plant intrinsic physiology by CA. To address these gaps, physiological, histochemical, and biochemical approaches were applied to investigate CA-facilitated cadmium (Cd) tolerance in the roots of tobacco (Nicotiana tabacum) seedlings. Treatment with CdCl2 at 20 μM for 72 h resulted in the significant decrease in root elongation by 40.39% as compared to control. CA alleviated Cd-inhibited root elongation in dose- and time-dependent manners. The addition of CA at 20 μM induced significant increase in root elongation by 42.58% as compared to Cd treatment alone. CA abolished Cd-induced ROS (reactive oxygen species) accumulation, lipid peroxidation, loss of membrane integrity, cell death, and free Cd2+ accumulation in roots. CA blocked the Cd-induced increase in the endogenous H2S level through the down-regulation of d-cysteine desulfhydrase (DCD) expression. H2S scavenger hypotaurine (HT) or potent H2S-biosynthetic inhibitor dl-propargylglicine (PAG) were able mimic the action of CA on the blockade of Cd-induced H2S accumulation, cell death, and growth inhibition. Enhancement of the endogenous H2S level with NaHS (H2S donor) abrogated all the beneficial capabilities of CA, HT, and PAG. Collectively, these results suggest that CA has great potential to confer plant tolerance against Cd stress, which is closely associated with its capability to inhibit Cd-induced H2S production. This study not only provides evidences for the regulation of plant physiology by CA but also sheds new light on the cross-talk between CA and H2S in physiological modulations. View Full-Text
Keywords: cinnamaldehyde; hydrogen sulfide; reactive oxygen species; cell death; cadmium; tobacco cinnamaldehyde; hydrogen sulfide; reactive oxygen species; cell death; cadmium; tobacco
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MDPI and ACS Style

Ye, X.-F.; Xue, Y.; Ling, T.; Wang, Y.; Yu, X.-N.; Cheng, C.; Feng, G.; Hu, L.; Shi, Z.; Chen, J. Cinnamaldehyde Ameliorates Cadmium-Inhibited Root Elongation in Tobacco Seedlings via Decreasing Endogenous Hydrogen Sulfide Production. Molecules 2017, 22, 15.

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