Next Article in Journal
Bio-Based Aromatic Epoxy Monomers for Thermoset Materials
Next Article in Special Issue
Wine Flavonoids in Health and Disease Prevention
Previous Article in Journal
The Performance of Several Docking Programs at Reproducing Protein–Macrolide-Like Crystal Structures
Previous Article in Special Issue
Kaempferol and Chrysin Synergies to Improve Septic Mice Survival
Article Menu
Issue 1 (January) cover image

Export Article

Open AccessArticle
Molecules 2017, 22(1), 110; doi:10.3390/molecules22010110

Inhibitory Effects of Constituents from the Aerial Parts of Rosmarinus officinalis L. on Triglyceride Accumulation

1
Tianjin State Key Laboratory of Modern Chinese Medicine, 312 Anshanxi Road, Nankai District, Tianjin 300193, China
2
Tianjin Key Laboratory of TCM Chemistry and Analysis, Institute of Traditional Chinese Medicine, Tianjin University of Traditional Chinese Medicine, 312 Anshanxi Road, Nankai District, Tianjin 300193, China
*
Authors to whom correspondence should be addressed.
Academic Editors: Celestino Santos-Buelga and Arturo San Feliciano
Received: 10 November 2016 / Revised: 26 December 2016 / Accepted: 8 January 2017 / Published: 17 January 2017
(This article belongs to the Special Issue Flavonoids: From Structure to Health Issues)
View Full-Text   |   Download PDF [4157 KB, uploaded 17 January 2017]   |  

Abstract

Sixteen flavonoids (116) including two new ones, named officinoflavonosides A (1) and B (2) were obtained from the aerial parts of Rosmarinus officinalis. Among the known ones, 6, 10, and 13 were isolated from the rosmarinus genus for the first time. Their structures were elucidated by chemical and spectroscopic methods. Moreover, the effects on sodium oleate-induced triglyceride accumulation (TG) in HepG2 cells of the above-mentioned compounds and 16 other isolates (1732) reported previously to have been obtained in the plant were analyzed. Results show that eight kinds of flavonoids (compounds 1, 2, 3, 69 and 11) and seven kinds of other known isolates (compounds 1720, 23, 26 and 31) possessed significant inhibitory effects on intracellular TG content in HepG2 cells. Among them, the activities of compounds 1 and 20 were comparable to that of orlistat, which suggested that these compounds in this plant might be involved in lipid metabolism. View Full-Text
Keywords: Rosmarinus officinalis; flavonoids; terpenoids; phenolic acids; triglyceride accumulation inhibitory effects; HepG2 cells Rosmarinus officinalis; flavonoids; terpenoids; phenolic acids; triglyceride accumulation inhibitory effects; HepG2 cells
Figures

Figure 1

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

Scifeed alert for new publications

Never miss any articles matching your research from any publisher
  • Get alerts for new papers matching your research
  • Find out the new papers from selected authors
  • Updated daily for 49'000+ journals and 6000+ publishers
  • Define your Scifeed now

SciFeed Share & Cite This Article

MDPI and ACS Style

Li, J.; Adelakun, T.A.; Wang, S.; Ruan, J.; Yang, S.; Li, X.; Zhang, Y.; Wang, T. Inhibitory Effects of Constituents from the Aerial Parts of Rosmarinus officinalis L. on Triglyceride Accumulation. Molecules 2017, 22, 110.

Show more citation formats Show less citations formats

Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Related Articles

Article Metrics

Article Access Statistics

1

Comments

[Return to top]

Molecules EISSN 1420-3049 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top