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Molecules 2017, 22(1), 1; doi:10.3390/molecules22010001

The Potential of Cyclodextrins as Novel Active Pharmaceutical Ingredients: A Short Overview

Drug Transport and Delivery Research Group, Department of Pharmacy, University of Tromsø, The Arctic University of Norway, 9019 Tromsø, Norway
Academic Editor: Bernard Martel
Received: 10 November 2016 / Revised: 7 December 2016 / Accepted: 16 December 2016 / Published: 25 December 2016
(This article belongs to the Special Issue Cyclodextrin Chemistry)
View Full-Text   |   Download PDF [1916 KB, uploaded 25 December 2016]   |  

Abstract

Cyclodextrins (CDs) are cyclic oligosaccharides of natural origin that were discovered more than 100 years ago. The peculiar cone-like conformation of the sugar ring, expressing a lipophilic cavity and a hydrophilic external surface, allows these substances to spontaneously complex poorly soluble compounds in an aqueous environment. For more than 50 years, these substances have found applicability in the pharmaceutical and food industries as solubilizing agents for poorly soluble chemical entities. Nowadays, several research groups all over the world are investigating their potential as active pharmaceutical ingredients (APIs) for the treatment of several illnesses (e.g., hypercholesterolemia, cancer, Niemann-Pick Type C disease). The aim of this review is to briefly retrace cyclodextrins’ legacy as complexing agents and describe the current and future prospects of this class of chemical entities in pharmaceutics as new APIs. View Full-Text
Keywords: cyclodextrins; inclusion complexes; solubilizing agents; cytotoxic activity; hypocholesterolemic agents; Niemann-Pick Type C disease treatment cyclodextrins; inclusion complexes; solubilizing agents; cytotoxic activity; hypocholesterolemic agents; Niemann-Pick Type C disease treatment
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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di Cagno, M.P. The Potential of Cyclodextrins as Novel Active Pharmaceutical Ingredients: A Short Overview. Molecules 2017, 22, 1.

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