Passerini Reactions on Biocatalytically Derived Chiral Azetidines
AbstractThe purpose of this study was to explore a series of Passerini reactions on a biocatalytically derived enantiopure azetidine-2-carboxyaldehyde in order to obtain, in a diastereoselective manner, polyfunctionalised derivatives having the potential to be cyclized to chiral bridged bicyclic nitrogen heterocycles. While diastereoselectivity was poor under classical Passerini conditions, a significant increase of diastereoselectivity (up to 76:24) was gained by the use of zinc bromide as promoter. The methodology has a broad scope and yields are always good. View Full-Text
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Moni, L.; Banfi, L.; Basso, A.; Bozzano, A.; Spallarossa, M.; Wessjohann, L.; Riva, R. Passerini Reactions on Biocatalytically Derived Chiral Azetidines. Molecules 2016, 21, 1153.
Moni L, Banfi L, Basso A, Bozzano A, Spallarossa M, Wessjohann L, Riva R. Passerini Reactions on Biocatalytically Derived Chiral Azetidines. Molecules. 2016; 21(9):1153.Chicago/Turabian Style
Moni, Lisa; Banfi, Luca; Basso, Andrea; Bozzano, Andrea; Spallarossa, Martina; Wessjohann, Ludger; Riva, Renata. 2016. "Passerini Reactions on Biocatalytically Derived Chiral Azetidines." Molecules 21, no. 9: 1153.
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