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Molecules 2016, 21(8), 1072; doi:10.3390/molecules21081072

Synthesis and Antimicrobial Activity of Some New Thiadiazoles, Thioamides, 5-Arylazothiazoles and Pyrimido[4,5-d][1,2,4]triazolo[4,3-a]pyrimidines

1
Department of Chemistry, Faculty of Science, Cairo University, Giza 12613, Egypt
2
Department of Chemistry, Faculty of Science, El Menoufia University, Shebin El Koom 32511, Egypt
3
Environmental Research Department, National Center for Social and Criminological Research, Ibn Khaldoun Square, Mohandesin, Zamalek, Giza 11561, Egypt
*
Author to whom correspondence should be addressed.
Academic Editor: Richard A. Bunce
Received: 25 June 2016 / Revised: 9 August 2016 / Accepted: 10 August 2016 / Published: 17 August 2016
(This article belongs to the Collection Heterocyclic Compounds)
View Full-Text   |   Download PDF [1615 KB, uploaded 17 August 2016]   |  

Abstract

A novel series of 1,3,4-thiadiazoles, 5-arylazothiazoles and hexahydropyrimido-[4,5-d][1,2,4]triazolo[4,3-a]pyrimidines were synthesized via reaction of hydrazonoyl halides with each of alkyl carbothioates, carbothioamides and 7-thioxo-5,6,7,8-tetrahydropyrimido-[4,5-d]pyrimidine-2,4(1H,3H)-diones in the presence of triethylamine. The structures of the newly synthesized compounds were established based on their spectral data, elemental analyses and alternative synthetic routes whenever possible. Also, the newly synthesized compounds were screened for their antimicrobial activity against various microorganisms. View Full-Text
Keywords: hydrazonoyl halides; thioamides; 1,3,4-thiadiazoles; thiazoles; pyrimido[4,5-d][1,2,4]triazolo[4,3-a]pyrimidines; antimicrobials hydrazonoyl halides; thioamides; 1,3,4-thiadiazoles; thiazoles; pyrimido[4,5-d][1,2,4]triazolo[4,3-a]pyrimidines; antimicrobials
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

Abdelhamid, A.O.; El Sayed, I.E.; Hussein, M.Z.; Mangoud, M.M. Synthesis and Antimicrobial Activity of Some New Thiadiazoles, Thioamides, 5-Arylazothiazoles and Pyrimido[4,5-d][1,2,4]triazolo[4,3-a]pyrimidines. Molecules 2016, 21, 1072.

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