Next Article in Journal
Salidroside Suppresses HUVECs Cell Injury Induced by Oxidative Stress through Activating the Nrf2 Signaling Pathway
Next Article in Special Issue
Synthesis and Antimicrobial Activity of Some New Thiadiazoles, Thioamides, 5-Arylazothiazoles and Pyrimido[4,5-d][1,2,4]triazolo[4,3-a]pyrimidines
Previous Article in Journal
Phytoestrogen Metabolism by Adult Human Gut Microbiota
Previous Article in Special Issue
Recent Advances in Metal-Free Quinoline Synthesis
Article Menu
Issue 8 (August) cover image

Export Article

Open AccessReview
Molecules 2016, 21(8), 1032; doi:10.3390/molecules21081032

Microwave-Assisted Syntheses of Bioactive Seven-Membered, Macro-Sized Heterocycles and Their Fused Derivatives

1
Laboratoire de Chimie des Plantes et de Synthèse Organique et Bioorganique, URAC23, Faculté des Sciences, Université Mohammed V, B.P. 1014 Rabat, Maroc
2
Institut de Chimie de Nice, ICN UMR UNS CNRS 7272, Université Nice-Sophia Antipolis-Université Côte d’Azur, Parc Valrose, 06108 Nice Cedex 2, France
3
Département de Chimie, Université Paris Descartes, Sorbonne Paris Cité, UFR des Sciences Pharmaceutiques, 4 avenue de l’Observatoire & UFR Biomédicale des Saints Pères, 45 Rue des Saints Pères, Paris Fr-75006, France
*
Authors to whom correspondence should be addressed.
Academic Editor: Philippe Belmont
Received: 17 June 2016 / Revised: 29 July 2016 / Accepted: 29 July 2016 / Published: 9 August 2016
(This article belongs to the Collection Heterocyclic Compounds)

Abstract

This review describes the recent advances in the microwave-assisted synthesis of 7-membered and larger heterocyclic compounds. Several types of reaction for the cyclization step are discussed: Ring Closing Metathesis (RCM), Heck and Sonogashira reactions, Suzuki-Miyaura cross-coupling, dipolar cycloadditions, multi-component reactions (Ugi, Passerini), etc. Green syntheses and solvent-free procedures have been introduced whenever possible. The syntheses discussed herein have been selected to illustrate the huge potential of microwave in the synthesis of highly functionalized molecules with potential therapeutic applications, in high yields, enhanced reaction rates and increased chemoselectivity, compared to conventional methods. More than 100 references from the recent literature are listed in this review. View Full-Text
Keywords: microwave irradiation; bioactive molecules; dipolar cycloaddition; cyclocondensations; multicomponent reactions microwave irradiation; bioactive molecules; dipolar cycloaddition; cyclocondensations; multicomponent reactions
Figures

Figure 1

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

Scifeed alert for new publications

Never miss any articles matching your research from any publisher
  • Get alerts for new papers matching your research
  • Find out the new papers from selected authors
  • Updated daily for 49'000+ journals and 6000+ publishers
  • Define your Scifeed now

SciFeed Share & Cite This Article

MDPI and ACS Style

Driowya, M.; Saber, A.; Marzag, H.; Demange, L.; Bougrin, K.; Benhida, R. Microwave-Assisted Syntheses of Bioactive Seven-Membered, Macro-Sized Heterocycles and Their Fused Derivatives. Molecules 2016, 21, 1032.

Show more citation formats Show less citations formats

Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Related Articles

Article Metrics

Article Access Statistics

1

Comments

[Return to top]

Molecules EISSN 1420-3049 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top